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Title: Parvalbumin Expression and Distribution in the Hippocampal Formation of Cebus apella
Authors: Torres, Laila Brito [UNIFESP]
Silva Araujo, Bruno Henrique [UNIFESP]
Marruaz, Klena Sarges
Souza, Janaina Sena de [UNIFESP]
Sousa, Bolivar Saldanha
Silva, Sergio Gomes da
Cabral, Francisco Romero
Cavalheiro, Esper Abrao [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Ctr Nacl Primatas CENP
Fac Ciencias Med Santa Casa São Paulo
Keywords: new world primates
CA2 layer
inhibitory interneurons
memory storage
Issue Date: 1-Apr-2015
Publisher: Wiley-Blackwell
Citation: American Journal of Primatology. Hoboken: Wiley-Blackwell, v. 77, n. 4, p. 449-461, 2015.
Abstract: New World primates play an important role in biomedical research. However, the literature still lacks information on many structural features of the brain in these species, particularly structures of the hippocampal formation that are related to long-term memory storage. This study was designed to provide information, for the first time, about the distribution and number of neurons expressing parvalbumin-immunoreactivity (PV-I) in the subregions of the hippocampal formation in Cebus apella, a New World primate species commonly used in biomedical research. Our results revealed that for several morphometric variables, PV-I cells differ significantly among the subregions CA1, CA2, CA3, and the hilus. Based upon our findings and those of other studies, we hypothesize that the proportional increase from monkeys to humans in PV-I cell density within CA1 is a factor contributing to the evolution of increased memory formation and storage. Am. J. Primatol. 77:449-461, 2015. (c) 2014 Wiley Periodicals, Inc.
ISSN: 0275-2565
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