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Title: Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
Authors: Silva, Avelar Alves de
Pacheco-Silva, Alvaro [UNIFESP]
Sesso, Ricardo de Castro Cintra [UNIFESP]
Esmeraldo, Ronaldo de Matos
Oliveira, Claudia Maria Costa de
Fernandes, Paula Frassinetti Castelo Branco Camurca
Oliveira, Rodrigo Alves de
Silva, Leila Silveira Veira de
Carvalho, Valencio Pereira de
Costa, Carlos Henrique Nery
Andrade, Jesusmar Ximenes
Silva, Diana Marisa Barros da
Chaves, Roosevelt Valente
Univ Fed Piaui
Hosp Alianca Casamater
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Gen Hosp Fortaleza
Univ Fed Ceara
Univ Crato
Keywords: Visceral leishmaniasis
Renal transplant recipients
Infection after transplant
Issue Date: 25-Feb-2015
Publisher: Biomed Central Ltd
Citation: Bmc Infectious Diseases. London: Biomed Central Ltd, v. 15, 10 p., 2015.
Abstract: Background: Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). in renal transplant recipients, visceral leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system, as well as poor outcomes for patients with transplanted kidneys. This study describes the largest series of cases of visceral leishmaniasis in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population.Methods: A retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with visceral leishmaniasis in the post-transplantation period.Results: in this study, visceral leishmaniasis was more frequent in men (80%). the mean age of presentation was 40 +/- 10.5 years. the majority of patients worked in urban areas (66.7%), cohabitated with domestic animals (90%), and were from low-income households. in 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. Patients were treated with liposomal amphotericin, resulting in a high degree of disease remission (80%).Conclusions: This study describes the largest series of visceral leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population.
ISSN: 1471-2334
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