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Title: Spectral-Domain Optical Coherence Tomography Measurements of Choroidal Thickness and Outer Retinal Disruption in Macular Telangiectasia Type 2
Authors: Nunes, Renata Portella [UNIFESP]
Goldhardt, Raquel
Amorim Garcia Filho, Carlos Alexandre de [UNIFESP]
Thorell, Mariana R.
Abbey, Ashkan M.
Kuriyan, Ajay E.
Modi, Yasha S.
Shah, Milan
Yehoshua, Zohar
Gregori, Giovanni
Feuer, William
Rosenfeld, Philip J.
Univ Miami
Universidade Federal de São Paulo (UNIFESP)
William Beaumont Hosp
Midwest Eye Inst
Issue Date: 1-Feb-2015
Publisher: Slack Inc
Citation: Ophthalmic Surgery Lasers & Imaging Retina. Thorofare: Slack Inc, v. 46, n. 2, p. 162-170, 2015.
Abstract: BACKGROUND and OBJECTIVE: To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared with healthy eyes.PATIENTS and METHODS: in this prospective, observational, cohort study, 62 patients (62 eyes) with MacTel2 and 130 healthy controls (130 eyes) underwent a complete ophthalmological examination, spectraldomain optical coherence tomography (SD-OCT) imaging, and axial length measurements. Patients in the study group also underwent color fundus photography, fundus autofluorescence, and fluorescein angiography. En face SD-OCT imaging was used to assess abnormalities involving the photoreceptor inner segment/outer segment/ellipsoid zone (IS/OS/EZ).RESULTS: After adjusting for age and axial length, the authors found that eyes with MacTel2 had a mean CT measurement that was greater than control eyes (P = .007). There was a negative correlation between the visual acuity and the area of IS/OS/EZ damage (P = .009), but no statistically significant correlation was seen between CT and the area of IS/OS/EZ damage.CONCLUSION: Eyes with MacTel2 were found to have thicker CT measurements than control eyes. While the extent of IS/OS/EZ disruption correlated with the loss of visual acuity, this damage did not correlate with CT measurements.
ISSN: 2325-8160
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