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Title: Different MOG(35-55) concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-beta in mice CNS despite unchanged clinical course
Authors: Dias, Alyria Teixeira
Ribeiro De Castro, Sandra Bertelli
De Souza Alves, Caio Cesar
Mesquita, Felipe Pereira
Visona De Figueiredo, Nathalia Stela
Evangelista, Marcilene Gomes
Marques Nogueira Castanon, Maria Christina
Juliano, Maria Aparecida [UNIFESP]
Ferreira, Ana Paula
Univ Fed Juiz de Fora
Fed Univ Valleys Jequitinhonha & Mucuri
Universidade Federal de São Paulo (UNIFESP)
Keywords: Multiple sclerosis
Animal model
Issue Date: 1-Feb-2015
Publisher: Elsevier B.V.
Citation: Cellular Immunology. San Diego: Academic Press Inc Elsevier Science, v. 293, n. 2, p. 87-94, 2015.
Abstract: Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. the factors involved in this heterogeneity remain unclear. the relevance of MUG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. the aim of this study was investigate if 100 or 300 mu g of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MUG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. the results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS. (C) 2015 Elsevier Inc. All rights reserved.
ISSN: 0008-8749
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