Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38669
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dc.contributor.authorTavares, Jose Gustavo P. [UNIFESP]
dc.contributor.authorVasques, E. R.
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorCabral, Francisco Romero
dc.contributor.authorTorres, Laila Brito
dc.contributor.authorMenezes-Rodrigues, Francisco Sandro [UNIFESP]
dc.contributor.authorJurkiewicz, Aron [UNIFESP]
dc.contributor.authorCaricati-Neto, Afonso [UNIFESP]
dc.contributor.authorGodoy, Carlos Marcelo G. [UNIFESP]
dc.contributor.authorGomes da Silva, Sergio
dc.date.accessioned2016-01-24T14:39:57Z-
dc.date.available2016-01-24T14:39:57Z-
dc.date.issued2015-02-01
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20144311
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 48, n. 2, p. 140-145, 2015.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38669-
dc.description.abstractThe present study evaluated electrocardiographic alterations in rats with epilepsy submitted to an acute myocardial infarction (AMI) model induced by cardiac ischemia and reperfusion. Rats were randomly divided into two groups: control (n=12) and epilepsy (n=14). It was found that rats with epilepsy presented a significant reduction in atrioventricular block incidence following the ischemia and reperfusion procedure. in addition, significant alterations were observed in electrocardiogram intervals during the stabilization, ischemia, and reperfusion periods of rats with epilepsy compared to control rats. It was noted that rats with epilepsy presented a significant increase in the QRS interval during the stabilization period in relation to control rats (P<0.01). During the ischemia period, there was an increase in the QRS interval (P<0.05) and a reduction in the P wave and QT intervals (P<0.05 for both) in rats with epilepsy compared to control rats. During the reperfusion period, a significant reduction in the QT interval (P<0.01) was verified in the epilepsy group in relation to the control group. Our results indicate that rats submitted to an epilepsy model induced by pilocarpine presented electrical conductivity alterations of cardiac tissue, mainly during an AMI episode.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT)
dc.format.extent140-145
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectEpilepsyen
dc.subjectHearten
dc.subjectAcute myocardial infarctionen
dc.subjectIschemiaen
dc.subjectReperfusionen
dc.titleEpilepsy-induced electrocardiographic alterations following cardiac ischemia and reperfusion in ratsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Iguacu
dc.contributor.institutionFac Minas
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniv Mogi das Cruzes
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, SP, Brazil
dc.description.affiliationUniv Iguacu, Itaperuna, RJ, Brazil
dc.description.affiliationFac Minas, Muriae, MG, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Gastroenterol, LIM 37, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, São Paulo, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Cerebro, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencia & Tecnol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Programa Integrado Engn Biomed, Nucleo Pesquisas Tecnol, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencia & Tecnol, Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipIDFAPESP: 09/069534
dc.identifier.fileS0100-879X2015000200140.pdf
dc.identifier.scieloS0100-879X2015000200140
dc.identifier.doi10.1590/1414-431X20144311
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000351598300006
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