Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38611
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dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorSilva, Sergio Gomes da [UNIFESP]
dc.contributor.authorAlmeida, Alexandre Aparecido de [UNIFESP]
dc.contributor.authorCavlheiro, Esper Abrao [UNIFESP]
dc.contributor.authorZavala-Tecuapetla, Cecilia
dc.contributor.authorBrand, Serge
dc.contributor.authorRocha, Luisa
dc.date.accessioned2016-01-24T14:39:52Z-
dc.date.available2016-01-24T14:39:52Z-
dc.date.issued2015-01-01
dc.identifierhttp://dx.doi.org/10.1111/jnc.12976
dc.identifier.citationJournal of Neurochemistry. Hoboken: Wiley-Blackwell, v. 132, n. 2, p. 206-217, 2015.
dc.identifier.issn0022-3042
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38611-
dc.description.abstractPhysical exercise stimulates the release of endogenous opioid peptides supposed to be responsible for changes in mood, anxiety, and performance. Exercise alters sensitivity to these effects that modify the efficacy at the opioid receptor. Although there is evidence that relates exercise to neuropeptide expression in the brain, the effects of exercise on opioid receptor binding and signal transduction mechanisms downstream of these receptors have not been explored. Here, we characterized the binding and G protein activation of mu opioid receptor, kappa opioid receptor or delta opioid receptor in several brain regions following acute (7 days) and chronic (30 days) exercise. As regards short-(acute) or longterm effects (chronic) of exercise, overall, higher opioid receptor binding was observed in acute-exercise animals and the opposite was found in the chronic-exercise animals. the binding of [S-35]GTP gamma S under basal conditions (absence of agonists) was elevated in sensorimotor cortex and hippocampus, an effect more evident after chronic exercise. Divergence of findings was observed for mu opioid receptor, kappa opioid receptor, and delta opioid receptor receptor activation in our study. Our results support existing evidence of opioid receptor binding and G protein activation occurring differentially in brain regions in response to diverse exercise stimuli.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT)
dc.description.sponsorshipNational Council for Sciences and Technology of Mexico
dc.format.extent206-217
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Neurochemistry
dc.rightsAcesso restrito
dc.subjectbrainen
dc.subjectDORen
dc.subjectexerciseen
dc.subjectKORen
dc.subjectMORen
dc.subjectopioid receptoren
dc.titleDifferential effects of exercise on brain opioid receptor binding and activation in ratsen
dc.typeArtigo
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionCtr Res & Adv Studies
dc.contributor.institutionUniv Basel
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Cerebro, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliationCtr Res & Adv Studies, Dept Pharmacobiol, Mexico City, DF, Mexico
dc.description.affiliationUniv Basel, Hosp Psychiat, Ctr Affect Stress & Sleep Disorders, Basel, Switzerland
dc.description.affiliationUniv Basel, Inst Exercise & Hlth Sci, Basel, Switzerland
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.sponsorshipIDNational Council for Sciences and Technology of Mexico: 98386
dc.identifier.doi10.1111/jnc.12976
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000348712000006
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