Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38611
Title: Differential effects of exercise on brain opioid receptor binding and activation in rats
Authors: Arida, Ricardo Mario [UNIFESP]
Silva, Sergio Gomes da [UNIFESP]
Almeida, Alexandre Aparecido de [UNIFESP]
Cavlheiro, Esper Abrao [UNIFESP]
Zavala-Tecuapetla, Cecilia
Brand, Serge
Rocha, Luisa
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Ctr Res & Adv Studies
Univ Basel
Keywords: brain
DOR
exercise
KOR
MOR
opioid receptor
Issue Date: 1-Jan-2015
Publisher: Wiley-Blackwell
Citation: Journal of Neurochemistry. Hoboken: Wiley-Blackwell, v. 132, n. 2, p. 206-217, 2015.
Abstract: Physical exercise stimulates the release of endogenous opioid peptides supposed to be responsible for changes in mood, anxiety, and performance. Exercise alters sensitivity to these effects that modify the efficacy at the opioid receptor. Although there is evidence that relates exercise to neuropeptide expression in the brain, the effects of exercise on opioid receptor binding and signal transduction mechanisms downstream of these receptors have not been explored. Here, we characterized the binding and G protein activation of mu opioid receptor, kappa opioid receptor or delta opioid receptor in several brain regions following acute (7 days) and chronic (30 days) exercise. As regards short-(acute) or longterm effects (chronic) of exercise, overall, higher opioid receptor binding was observed in acute-exercise animals and the opposite was found in the chronic-exercise animals. the binding of [S-35]GTP gamma S under basal conditions (absence of agonists) was elevated in sensorimotor cortex and hippocampus, an effect more evident after chronic exercise. Divergence of findings was observed for mu opioid receptor, kappa opioid receptor, and delta opioid receptor receptor activation in our study. Our results support existing evidence of opioid receptor binding and G protein activation occurring differentially in brain regions in response to diverse exercise stimuli.
URI: http://repositorio.unifesp.br/handle/11600/38611
ISSN: 0022-3042
Other Identifiers: http://dx.doi.org/10.1111/jnc.12976
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