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Title: Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials
Authors: Marta, Gustavo Nader
Macedo, Cristiane Rufino de [UNIFESP]
Carvalho, Heloisa de Andrade
Hanna, Samir Abdallah
Fernandes da Silva, Joao Luis
Riera, Rachel [UNIFESP]
Hosp Sirio Libanes
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Breast cancer
Breast-conserving therapy
Whole-breast irradiation
Accelerated partial breast irradiation
Issue Date: 1-Jan-2015
Publisher: Elsevier B.V.
Citation: Radiotherapy and Oncology. Clare: Elsevier B.V., v. 114, n. 1, p. 42-49, 2015.
Abstract: Background and purpose: Accelerated partial breast irradiation (APBI) is the strategy that allows adjuvant treatment delivery in a shorter period of time in smaller volumes. This study was undertaken to assess the effectiveness and outcomes of APBI in breast cancer compared with whole-breast irradiation (WBI). Material and methods: Systematic review and meta-analysis of randomized controlled trials of WBI versus APBI. Two authors independently selected and assessed the studies regarding eligibility criteria. Results: Eight studies were selected. A total of 8653 patients were randomly assigned for WBI versus APBI. Six studies reported local recurrence outcomes. Two studies were matched in 5 years and only one study for different time of follow-up. Meta-analysis of two trials assessing 1407 participants showed significant difference in the WBI versus APBI group regarding the 5-year local recurrence rate (HR = 4.54, 95% CI: 1.78-11.61, p = 0.002). Significant difference in favor of WBI for different follow-up times was also found. No differences in nodal recurrence, systemic recurrence, overall survival and mortality rates were observed. Conclusions: APBI is associated with higher local recurrence compared to WBI without compromising other clinical outcomes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0167-8140
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