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Title: Perinatal factors associated with early neonatal deaths in very low birth weight preterm infants in Northeast Brazil
Authors: Castro, Eveline Campos Monteiro de
Leite, Alvaro Jorge Madeiro
Almeida, Maria Fernanda Branco de [UNIFESP]
Guinsburg, Ruth [UNIFESP]
Univ Fed Ceara
Universidade Federal de São Paulo (UNIFESP)
Keywords: Premature newborn infant
Very low weight newborn infant
Neonatal mortality
Early neonatal mortality
Neonatal ICU
Issue Date: 20-Dec-2014
Publisher: Biomed Central Ltd
Citation: Bmc Pediatrics. London: Biomed Central Ltd, v. 14, 8 p., 2014.
Abstract: Background: in Brazil, the prevalence of prematurity has increased in recent years and it is a major cause of death in the neonatal period. Therefore, this study aims at assessing perinatal factors associated with early neonatal deaths in very low birth weight preterm infants born in a region of Brazil with low Human Development Index.Methods: Prospective cohort study of inborns with gestational age 23(0/7)-31(6/7) weeks and birthweight 500-1499 g without malformations in 19 public reference hospitals of the state capitals of Brazil's Northeast Region. Perinatal variables associated with early neonatal death were determined by Cox regression analysis.Result: Among 627 neonates, 179 (29%) died with 0-6 days after birth. Early death was associated to: absence of antenatal steroids (HR 1.59; 95% CI 1.11-2.27), multiple gestation (1.95; 1.28-3.00), male sex (2.01; 1.40-2.86), 5th minute Apgar <7 (2.93; 2.03-4.21), birthweight <1000 g (2.58; 1.70-3.88), gestational age <28 weeks (2.07; 1.42-3.02), use of surfactant (1.65; 1.04-2.59), and non-use of a pain scale (1.89; 1.24-2.89).Conclusion: Biological variables and factors related to the quality of perinatal care were associated with the high chance of early death of preterm infants born in reference hospitals of Northeast Brazil.
ISSN: 1471-2431
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