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Title: Late-Onset Sepsis in very Low Birth Weight Infants: A Brazilian Neonatal Research Network Study
Authors: Suppo de Souza Rugolo, Ligia Maria
Bentlin, Maria Regina
Mussi-Pinhata, Marisa
Branco de Almeida, Maria Fernanda [UNIFESP]
Andrade Lopes, Jose Maria de
Martins Marba, Sergio Tadeu
Fiori, Humberto Holmer
Procianoy, Renato Soibelmann
Leone, Clea Rodrigues
Brazilian Network Neonatal Res
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fundacao Oswaldo Cruz
Pontificia Univ Catolica Rio Grande do Sul
Univ Fed Rio Grande do Sul
Keywords: Sepsis
newborn infant
very low birth weight
Issue Date: 1-Dec-2014
Publisher: Oxford Univ Press
Citation: Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 60, n. 6, p. 415-421, 2014.
Abstract: Background: Late-onset sepsis (LOS) is an important cause of morbidity and mortality in very low birth weight (VLBW) infants.Aim: To determine the incidence, risk factors and etiology of LOS.Methods: LOS was investigated in a multicenter prospective cohort of infants at eight public university neonatal intensive care units (NICUs). Inclusion criteria included inborn, 23-33 weeks of gestational age, 400-1499 g birth weight, who survived >3 days.Results: of 1507 infants, 357 (24%) had proven LOS and 345 (23%) had clinical LOS. Infants with LOS were more likely to die. the majority of infections (76%) were caused by Gram-positive organisms. Independent risk factors for proven LOS were use of central venous catheter and mechanical ventilation, age at the first feeding and number of days on parenteral nutrition and on mechanical ventilation.Conclusion: LOS incidence and mortality are high in Brazilian VLBW infants. Most risk factors are associated with routine practices at NICU.
ISSN: 0142-6338
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