Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38479
Title: Brazilian embauba (Cecropia pachystachya) extract reduces renal lesions in 5/6 nephrectomized rats
Authors: Maquiaveli, Claudia do C.
Silva, Edson R. da
Francescato, Heloisa D. C.
Costa, Roberto S.
Silva, Cleonice G. A.
Casarini, Dulce Elena [UNIFESP]
Ronchi, Fernanda A. [UNIFESP]
Coimbra, Terezila M.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Cecropia pachystachya
renal failure
angiotensin II
inflammation
Issue Date: 1-Dec-2014
Publisher: Sage Publications Ltd
Citation: Journal of the Renin-angiotensin-aldosterone System. London: Sage Publications Ltd, v. 15, n. 4, p. 430-439, 2014.
Abstract: Introduction:Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This study evaluated the CP extract effect on renal lesions provoked by 5/6 NE.Materials and methods: Male Wistar rats submitted to 5/6 NE were treated or not treated with CP extract and followed for 90 days. Systemic blood pressure (SBP), albuminuria, renal functional and structural parameters, ACE activity, urinary levels of monocyte chemoattrant protein-1 (MCP-1) and transforming growth factor (TGF-) were evaluated.Results: Albuminuria and hypertension were less intense in the treated (NE+CP) group compared to the untreated (NE) group. CP extract treatment reduced the fall in glomerular filtration rate observed in NE rats. Glomerulosclerosis, tubulointerstitial lesions, increase of macrophages and AII positive cells in the renal cortex, as well as increases in renal ACE activity, urinary levels of MCP-1 and TGF- were attenuated in NE rats by CP treatment.Conclusions: the treatment with CP extract reduced the SBP and functional and structural renal changes in 5/6 NE rats. These effects were associated with decreased AII expression, ACE activity and inflammation in the renal cortex.
URI: http://repositorio.unifesp.br/handle/11600/38479
ISSN: 1470-3203
Other Identifiers: http://dx.doi.org/10.1177/1470320313501219
Appears in Collections:Em verificação - Geral

Files in This Item:
File Description SizeFormat 
WOS000346269600011.pdf799.85 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.