Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38409
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dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorSantoro, Marcos Leite [UNIFESP]
dc.contributor.authorSpindola, Leticia Maria [UNIFESP]
dc.contributor.authorGouvea, Eduardo Sauerbronn [UNIFESP]
dc.contributor.authorStilhano, Roberta Sessa [UNIFESP]
dc.contributor.authorOrtiz, Bruno Bertolucci [UNIFESP]
dc.contributor.authorSilva, Patricia Natalia [UNIFESP]
dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorHan, Sang Won [UNIFESP]
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.date.accessioned2016-01-24T14:38:07Z-
dc.date.available2016-01-24T14:38:07Z-
dc.date.issued2014-11-01
dc.identifierhttp://dx.doi.org/10.1016/j.schres.2014.09.008
dc.identifier.citationSchizophrenia Research. Amsterdam: Elsevier B.V., v. 159, n. 2-3, p. 358-364, 2014.
dc.identifier.issn0920-9964
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38409-
dc.description.abstractSchizophrenia is a severe mental health disorder with high heritability. the investigation of individuals during their first-episode psychosis (FEP), before the progression of psychotic disorders and especially before treatment with antipsychotic medications, is particularly helpful for understanding this complex disease and for the identification of potential biomarkers. in this study, we compared the expression of genes that are involved in neurotransmission and neurodevelopment of antipsychotic-naive FEP in the peripheral blood of patients (n=51) and healthy controls (n=51). in addition, we investigated the differentially expressed genes with respect to a) DNA methylation, b) the correlation between gene expression and clinical variables (PANSS), and c) gene expression changes after risperidone treatment. Expression levels of 11 genes were quantified with SYBR Green. for methylation analysis, bisulfite sequencing was performed. A significant decrease in GCH1 mRNA levels was observed in FEP patients relative to controls. Also, when we compare the FEP patients after risperidone treatment with controls, this difference remains significant, and no significant differences were observed in GCH1 mRNA levels when comparing patients before and after risperidone treatment. Additionally, although the differences were non-significant after Bonferroni correction, the expression of GCH1 seemed to be correlated with PANSS scores, and the GCH1 promoter region was more methylated in FEP than in controls, thus corroborating the results obtained at the mRNA level. Few studies have been conducted on GCH1, and future studies are needed to clarify its potential role in the progression of schizophrenia. (C) 2014 Elsevier B. V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent358-364
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSchizophrenia Research
dc.rightsAcesso restrito
dc.subjectgene expressionen
dc.subjectBH4en
dc.subjectbiopterinen
dc.subjectGTP cyclohydrolase Ien
dc.subjectschizophreniaen
dc.titleChanges in gene expression and methylation in the blood of patients with first-episode psychosisen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionISCMSP
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Morphol & Genet, Div Genet, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, LiNC Interdisciplinary Lab Clin Neurosci, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, BR-04023900 São Paulo, Brazil
dc.description.affiliationISCMSP, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Morphol & Genet, Div Genet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, LiNC Interdisciplinary Lab Clin Neurosci, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2010/08968-6
dc.description.sponsorshipIDFAPESP: 2010/19176-3
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDFAPESP: 2013/10498-6
dc.identifier.doi10.1016/j.schres.2014.09.008
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000345229200018
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