Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/38382
Title: Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats
Authors: Pereira da Silva, Victor Hugo [UNIFESP]
Gomes de Moura, Carolina Foot [UNIFESP]
Pidone Ribeiro, Flavia Andressa [UNIFESP]
Cesar, Augusto [UNIFESP]
Pereira, Camilo Dias Seabra [UNIFESP]
Dias Silva, Marcelo Jose
Vilegas, Wagner
Ribeiro, Daniel Araki [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
São Paulo State Univ
Keywords: Municipal effluent
Apoptosis
Mutagenicity
DNA damage
Rat
Issue Date: 1-Nov-2014
Publisher: Springer
Citation: Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 22, p. 13069-13080, 2014.
Abstract: The aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100% for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100% concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p<0.05) for micronucleated cells from liver were noticed at 50% concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.
URI: http://repositorio.unifesp.br/handle/11600/38382
ISSN: 0944-1344
Other Identifiers: http://dx.doi.org/10.1007/s11356-014-3261-5
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