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Title: Non-pupillary block angle-closure mechanisms: a comprehensive analysis of their prevalence and treatment outcomes
Other Titles: Mecanismos de fechamento angular sem bloqueio pupilar: análise de prevalência e resultados terapêuticos
Authors: Junqueira, Daniela L. M.
Prado, Vitor G. [UNIFESP]
Lopes, Flavio S. [UNIFESP]
Biteli, Luis Gustavo [UNIFESP]
Dorairaj, Syril
Prata, Tiago S. [UNIFESP]
Hosp Med Olhos
Universidade Federal de São Paulo (UNIFESP)
Mayo Clin
Keywords: Angle closure
Non-pupillary block mechanisms
Iris diseases
Treatment outcome
Issue Date: 1-Nov-2014
Publisher: Consel Brasil Oftalmologia
Citation: Arquivos Brasileiros de Oftalmologia. São Paulo: Consel Brasil Oftalmologia, v. 77, n. 6, p. 360-363, 2014.
Abstract: Purpose: To assess the prevalence and treatment outcomes of angle-closure mechanisms other than pupillary block in a population of Brazilian patients.Methods: A retrospective chart review was conducted to evaluate patients who had undergone laser peripheral iridotomy (LPI) due to occludable angles at a single institution between July 2009 and April 2012. An occludable angle was defined as an eye in which the posterior trabecular meshwork was not visible for >= 180 degrees on dark-room gonioscopy. Key exclusion criteria were any form of secondary glaucoma and the presence of >90 degrees of peripheral anterior synechiae. Collected data were age, race, gender, angle-closure mechanism (based on indentation goniocopy and ultrasound biomicroscopy), intraocular pressure (IOP), number of antiglaucoma medications and subsequent management during follow-up. If both eyes were eligible, the right eye was arbitrarily selected for analysis.Results: A total of 196 eyes of 196 consecutive patients (mean age 58.3 +/- 11.6 years) who underwent LPI were included. in most of the patients [86% (169 patients; 133 women and 36 men]), LPI sucessfully opened the angle. Mean IOP was reduced from 18.3 +/- 6.4 mmHg to 15.4 +/- 4.5 mmHg after LPI (p<0.01). Among the 27 patients with persistent occludable angles, the most common underlying mechanisms were plateau iris (56%) and lens-induced component (34%). Most of these patients (85%) were treated with argon laser peripheral iridoplasty (ALPI); approximately 90% showed non-occludable angles following the laser procedure (mean IOP reduction of 18.9%), with no significant differences between patients with plateau iris and lens-induced components (p=0.34; mean follow-up of 11.4 +/- 3.6 months).Conclusions: Our findings suggest that, in this population of Brazilian patients, several eyes with angle closure were not completely treated with LPI. in the present large case series involving middle-age patients, plateau iris was the leading cause of persistent angle closure and was effectively treated with ALPI. A detailed eye examination with indentation gonioscopy should always be performed after LPI to rule out persistent angle closure due to non-pupillary block mechanisms.
ISSN: 0004-2749
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