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|Title:||Effect of dietary lipids on circulating adiponectin: a systematic review with meta-analysis of randomised controlled trials|
|Authors:||von Frankenberg, Anize D.|
Silva, Flavia M.
Almeida, Jussara C. de
Nascimento, Filipe V. do
Sost, Monica M.
Leitao, Cristiane B.
Remonti, Luciana L. R.
Reis, Andre F. [UNIFESP]
Canani, Luis H.
Azevedo, Mirela J. de
Univ Fed Rio Grande do Sul
Hosp Clin Porto Alegre
Universidade Federal de São Paulo (UNIFESP)
Conjugated linoleic acid
|Publisher:||Cambridge Univ Press|
|Citation:||British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 112, n. 8, p. 1235-1250, 2014.|
|Abstract:||Different dietary interventions have been identified as potential modifiers of adiponectin concentrations, and they may be influenced by lipid intake. We identified studies investigating the effect of dietary lipids (type/amount) on adiponectin concentrations in a systematic review with meta-analysis. A literature search was conducted until July 2013 using databases such as Medline, Embase and Scopus (MeSH terms: adiponectin', dietary lipid', randomized controlled trials (RCT)'). Inclusion criteria were RCT in adults analysing adiponectin concentrations with modification of dietary lipids. Among the 4930 studies retrieved, fifty-three fulfilled the inclusion criteria and were grouped as follows: (1) total dietary lipid intake; (2) dietary/supplementary n-3 PUFA; (3) conjugated linoleic acid (CLA) supplementation; (4) other dietary lipid interventions. Diets with a low fat content in comparison to diets with a high-fat content were not associated with positive changes in adiponectin concentrations (twelve studies; pooled estimate of the difference in means: -004 (95% CI -082, 074)g/ml). A modest increase in adiponectin concentrations with n-3 PUFA supplementation was observed (thirteen studies; 027 (95% CI 007, 047)g/ml). Publication bias was found by using Egger's test (P=001) and funnel plot asymmetry. in contrast, CLA supplementation reduced the circulating concentrations of adiponectin compared with unsaturated fat supplementation (seven studies; -074 (95% CI -138, -010)g/ml). However, important sources of heterogeneity were found as revealed by the meta-regression analyses of both n-3 PUFA and CLA supplementation. Results of new RCT would be necessary to confirm these findings.|
|Appears in Collections:||Em verificação - Geral|
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