Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38330
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dc.contributor.authorSouza, Carolina Rosal Teixeira de
dc.contributor.authorOliveira, Katia Soares de
dc.contributor.authorFerraz, Jefferson Jose Sodre
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorSeabra, Aline Damasceno
dc.contributor.authorKhayat, Andre Salim
dc.contributor.authorMontenegro, Raquel Carvalho
dc.contributor.authorAlves, Ana Paula Negreiros Nunes
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.date.accessioned2016-01-24T14:38:00Z-
dc.date.available2016-01-24T14:38:00Z-
dc.date.issued2014-10-15
dc.identifierhttp://dx.doi.org/10.1186/1471-230X-14-179
dc.identifier.citationBmc Gastroenterology. London: Biomed Central Ltd, v. 14, 9 p., 2014.
dc.identifier.issn1471-230X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38330-
dc.description.abstractBackground: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA(+) and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE).Methods: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA by a urease test and PCR. the presence of EBV was detected by Eber-1 in situ hybridization.Results: in UE, 85.5% of juvenile patients showed some degree of gastritis (45.3% of patients with mild gastritis and 54.7% with moderate/severe gastritis) and patients with mild gastritis were younger than patients with moderate/severe gastritis. Among adults, 48.7% presented mild gastritis and 51.3% moderate/severe gastritis. HP infection was detected in 0% of normal mucosa, 58.5% of juvenile gastritis patients, 69.2% of adult gastritis patients and 88% of GC patients. in these same groups, HP CagA(+) was detected in 0%, 37.7%, 61.5% and 67.2% of tissue samples, respectively. in juvenile patients, HP infection was more common in those with gastritis than in normal samples (p = 0.004). the patients with either HP or HP CagA(+) were older than patients without these pathogens (p < 0.05). in juvenile patients, HP infection was more frequent in cases of moderate/severe gastritis than in cases of mild gastritis (p = 0.026). Moreover, in patients with GC, HP infection was more frequent in males than in females (p = 0.023). GC patients with HP CagA(+) were older than patients with HP CagA-(p = 0.027). HP CagA(+) was more common in intestinal-type than diffuse-type GC (p = 0.012). HP CagA(+) was also associated with lymph-node (p = 0.024) and distal (p = 0.005) metastasis. No association between EBV infection and HP infection or any clinicopathological variable was detected.Conclusions: Our results suggest that HP is involved in the pathophysiology of severe gastric lesions and in the development of GC, particularly when CagA(+) is present. EBV was not the primary pathogenic factor in our samples.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent9
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Gastroenterology
dc.rightsAcesso aberto
dc.subjectHelicobacter pylorien
dc.subjectEpstein-Barr virusen
dc.subjectGastritisen
dc.subjectGastric canceren
dc.titleOccurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazilen
dc.typeArtigo
dc.contributor.institutionFed Univ Para
dc.contributor.institutionCtr Univ Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Ceara
dc.description.affiliationFed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, PA, Brazil
dc.description.affiliationFed Univ Para, Inst Ciencias Saude, BR-66075110 Belem, PA, Brazil
dc.description.affiliationCtr Univ Para, Belem, PA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, São Paulo, Brazil
dc.description.affiliationFed Univ Para, BR-66075110 Belem, PA, Brazil
dc.description.affiliationUniv Fed Ceara, Fac Odontol, Dept Oral Pathol, Fortaleza, CE, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morfol & Genet, Disciplina Genet, São Paulo, Brazil
dc.identifier.fileWOS000346673400001.pdf
dc.identifier.doi10.1186/1471-230X-14-179
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000346673400001
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