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dc.contributor.authorSilva-Pereira, Liz Carmem
dc.contributor.authorMachado da Rocha, Carlos Alberto
dc.contributor.authorCampos da Silva e Cunha, Luiz Raimundo
dc.contributor.authorCosta, Edmar Tavares da
dc.contributor.authorAraujo Guimaraes, Ana Paula
dc.contributor.authorPontes, Thais Brilhante
dc.contributor.authorWanderley Picanco Diniz, Domingos Luiz
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorMoreira-Nunes, Caroline Aquino
dc.contributor.authorBurbano, Rommel Rodriguez
dc.identifier.citationInternational Journal of Environmental Research and Public Health. Basel: Mdpi Ag, v. 11, n. 9, p. 9822-9834, 2014.
dc.description.abstractMercury exhibits cytotoxic and mutagenic properties as a result of its effect on tubulin. This toxicity mechanism is related to the production of free radicals that can cause DNA damage. Methylmercury (MeHg) is one of the most toxic of the mercury compounds. It accumulates in the aquatic food chain, eventually reaching the human diet. Several studies have demonstrated that prolactin (PRL) may be differently affected by inorganic and organic mercury based on interference with various neurotransmitters involved in the regulation of PRL secretion. This study evaluated the cytoprotective effect of PRL on human lymphocytes exposed to MeHg in vitro, including observation of the kinetics of HL-60 cells (an acute myeloid leukemia lineage) treated with MeHg and PRL at different concentrations, with both treatments with the individual compounds and combined treatments. All treatments with MeHg produced a significant increase in the frequency of chromatid gaps, however, no significant difference was observed in the chromosomal breaks with any treatment. A dose-dependent increase in the mitotic index was observed for treatments with PRL, which also acts as a co-mitogenic factor, regulating proliferation by modulating the expression of genes that are essential for cell cycle progression and cytoskeleton organization. These properties contribute to the protective action of PRL against the cytotoxic and mutagenic effects of MeHg.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal of Environmental Research and Public Health
dc.rightsAcesso aberto
dc.subjectmitotic indexen
dc.titleProtective Effect of Prolactin against Methylmercury-Induced Mutagenicity and Cytotoxicity on Human Lymphocytesen
dc.contributor.institutionIFPA Itaituba
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniv Para
dc.contributor.institutionFed Univ Western Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationIFPA Itaituba, Fed Inst Educ Sci & Technol Para, BR-68180000 Campinas, Para, Brazil
dc.description.affiliationFed Univ Para, Inst Biol Sci, BR-66075110 Belem, Para, Brazil
dc.description.affiliationIFPA, Educ Fed Inst Sci & Technol Para, BR-66645240 Belem, Para, Brazil
dc.description.affiliationUniv Para, Ctr Biol & Hlth Sci, BR-66050540 Belem, Para, Brazil
dc.description.affiliationFed Univ Western Para, UFOPA, BR-68040470 Santarem, Para, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04021001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04021001 São Paulo, Brazil
dc.description.sourceWeb of Science
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