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Title: Protective Effect of Prolactin against Methylmercury-Induced Mutagenicity and Cytotoxicity on Human Lymphocytes
Authors: Silva-Pereira, Liz Carmem
Machado da Rocha, Carlos Alberto
Campos da Silva e Cunha, Luiz Raimundo
Costa, Edmar Tavares da
Araujo Guimaraes, Ana Paula
Pontes, Thais Brilhante
Wanderley Picanco Diniz, Domingos Luiz
Leal, Mariana Ferreira [UNIFESP]
Moreira-Nunes, Caroline Aquino
Burbano, Rommel Rodriguez
IFPA Itaituba
Fed Univ Para
Univ Para
Fed Univ Western Para
Universidade Federal de São Paulo (UNIFESP)
Keywords: methylmercury
mitotic index
Issue Date: 1-Sep-2014
Publisher: Mdpi Ag
Citation: International Journal of Environmental Research and Public Health. Basel: Mdpi Ag, v. 11, n. 9, p. 9822-9834, 2014.
Abstract: Mercury exhibits cytotoxic and mutagenic properties as a result of its effect on tubulin. This toxicity mechanism is related to the production of free radicals that can cause DNA damage. Methylmercury (MeHg) is one of the most toxic of the mercury compounds. It accumulates in the aquatic food chain, eventually reaching the human diet. Several studies have demonstrated that prolactin (PRL) may be differently affected by inorganic and organic mercury based on interference with various neurotransmitters involved in the regulation of PRL secretion. This study evaluated the cytoprotective effect of PRL on human lymphocytes exposed to MeHg in vitro, including observation of the kinetics of HL-60 cells (an acute myeloid leukemia lineage) treated with MeHg and PRL at different concentrations, with both treatments with the individual compounds and combined treatments. All treatments with MeHg produced a significant increase in the frequency of chromatid gaps, however, no significant difference was observed in the chromosomal breaks with any treatment. A dose-dependent increase in the mitotic index was observed for treatments with PRL, which also acts as a co-mitogenic factor, regulating proliferation by modulating the expression of genes that are essential for cell cycle progression and cytoskeleton organization. These properties contribute to the protective action of PRL against the cytotoxic and mutagenic effects of MeHg.
ISSN: 1660-4601
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