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Title: Genome of the Avirulent Human-Infective Trypanosome-Trypanosoma rangeli
Authors: Stoco, Patricia Hermes
Wagner, Glauber
Talavera-Lopez, Carlos
Gerber, Alexandra
Zaha, Arnaldo
Thompson, Claudia Elizabeth
Bartholomeu, Daniella Castanheira
Lueckemeyer, Debora Denardin
Bahia, Diana [UNIFESP]
Loreto, Elgion
Prestes, Elisa Beatriz
Lima, Fabio Mitsuo [UNIFESP]
Rodrigues-Luiz, Gabriela
Adolfo Vallejo, Gustavo
Franco da Silveira, José [UNIFESP]
Schenkman, Sergio [UNIFESP]
Monteiro, Karina Mariante
Tyler, Kevin Morris
Paula de Almeida, Luiz Gonzaga
Ortiz, Mauro Freitas
Chiurillo, Miguel Angel [UNIFESP]
Moraes, Milene Hoeehr de
Cunha, Oberdan de Lima
Mendonca-Neto, Rondon
Silva, Rosane
Ribeiro Teixeira, Santuza Maria
Fonseca Murta, Silvane Maria
Marques Sincero, Thais Cristine
Oliveira Mendes, Tiago Antonio de
Urmenyi, Turan Peter
Silva, Viviane Grazielle
Rocha, Wanderson Duarte da
Andersson, Bjoern
Romanha, Alvaro Jose
Steindel, Mario
Ribeiro de Vasconcelos, Ana Tereza
Grisard, Edmundo Carlos
Universidade Federal de Santa Catarina (UFSC)
Univ Oeste Santa Catarina
Karolinska Inst
Lab Nacl Comp Cient
Univ Fed Rio Grande do Sul
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Sergipe (UFS)
Univ Tolima
Univ E Anglia
Univ Centroccidental Lisandro Alvarado
Universidade Federal do Rio de Janeiro (UFRJ)
Fundacao Oswaldo Cruz
Univ Fed Parana
Issue Date: 1-Sep-2014
Publisher: Public Library Science
Citation: Plos Neglected Tropical Diseases. San Francisco: Public Library Science, v. 8, n. 9, 17 p., 2014.
Abstract: Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.Methodology/Principal Findings: the T. rangeli haploid genome is similar to 24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heat-shock proteins.Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. in addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets.
ISSN: 1935-2735
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