Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38086
Title: Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice
Authors: Moreno, Mayara Franzoi [UNIFESP]
De Laquila, Rachel [UNIFESP]
Okuda, Marcos Hiromu [UNIFESP]
Lira, Fabio Santos de [UNIFESP]
Souza, Gabriel Inacio de Morais Honorato de [UNIFESP]
Souza, Claudio Teodoro de
Telles, Monica Marques [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fac Integradas Coracao Jesus FAINC
Univ Estadual Paulista
Univ Southern Santa Catarina
Keywords: High-fat diet
Adipokines
Adipose tissue
Inflammation
Issue Date: 12-Aug-2014
Publisher: Biomed Central Ltd
Citation: Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014.
Abstract: Background: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. the consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.
URI: http://repositorio.unifesp.br/handle/11600/38086
ISSN: 1758-5996
Other Identifiers: http://dx.doi.org/10.1186/1758-5996-6-84
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