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Title: Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system
Authors: Rial, Daniel
Pamplona, Fabricio A.
Moreira, Eduardo L. G.
Moreira, Karin M. [UNIFESP]
Hipolide, Debora [UNIFESP]
Rodrigues, Diana I.
Dombrowski, Patricia A.
Da Cunha, Claudio
Agostinho, Paula
Takahashi, Reinaldo N.
Walz, Roger
Cunha, Rodrigo A.
Prediger, Rui D.
Universidade Federal de Santa Catarina (UFSC)
Rua Larga Univ Coimbra
DOr Inst Res & Educ
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná (UFPR)
Univ Coimbra
Hosp Governador Celso Ramos
Keywords: behavior
cellular prion protein
dopamine receptor
Issue Date: 1-Aug-2014
Publisher: Wiley-Blackwell
Citation: European Journal of Neuroscience. Hoboken: Wiley-Blackwell, v. 40, n. 3, p. 2479-2486, 2014.
Abstract: Cellular prion protein (PrPC) is widely expressed in the brain. Although the precise role of PrPC remains uncertain, it has been proposed to be a pivotal modulator of neuroplasticity events by regulating the glutamatergic and serotonergic systems. Here we report the existence of neurochemical and functional interactions between PrPC and the dopaminergic system. PrPC was found to co-localize with dopaminergic neurons and in dopaminergic synapses in the striatum. Furthermore, the genetic deletion of PrPC down-regulated dopamine D-1 receptors and DARPP-32 density in the striatum and decreased dopamine levels in the prefrontal cortex of mice. This indicates that PrPC affects the homeostasis of the dopaminergic system by interfering differently in different brain areas with dopamine synthesis, content, receptor density and signaling pathways. This interaction between PrPC and the dopaminergic system prompts the hypotheses that the dopaminergic system may be implicated in some pathological features of prion-related diseases and, conversely, that PrPC may play a role in dopamine-associated brain disorders.
ISSN: 0953-816X
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Appears in Collections:Artigo

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