Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38040
Title: Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide
Authors: Pidone Ribeiro, Flavia Andressa [UNIFESP]
Gomes de Moura, Carolina Foot [UNIFESP]
Boiago Gollucke, Andrea Pitelli
Ferreira, Monica Siqueira
Catharino, Rodrigo Ramos
Aguiar, Odair [UNIFESP]
Spadari, Regina Celia [UNIFESP]
Barbisan, Luis Fernando
Ribeiro, Daniel Araki [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Catholic Santos Univ
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Keywords: Apple extract
4-Nitroquinoline-1-oxide
Oral cancer
Inflammation
Apoptosis
Issue Date: 1-Aug-2014
Publisher: Elsevier B.V.
Citation: Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V., v. 59, n. 8, p. 815-821, 2014.
Abstract: Objective: the aim of this study was to evaluate the chemopreventive activity of an apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide (4NQO).Methods: A total of 30 male Wistar rats were distributed into five groups as follows (n = 6 per group): Group 1, negative control group (non-treated group); Group 2, received 4NQO during 8 weeks in drinking water and treated with apple extract at 1% by gavage between the first and fourth weeks daily (initiation phase); Group 3, received 4NQO for 8 weeks in drinking water and treated with apple extract by gavage at 1% between the fifth and eighth weeks daily (promotion phase); Group 4, received apple extract at 1% by gavage for 8 consecutive weeks only; and Group 5, received 4NQO for 8 weeks in drinking water daily.Results: Histopathological analysis revealed decreased hyperplasic lesions in Group 2 when compared with Group 5. Likewise, decreased dysplastic lesions in Group 3 were observed when compared with Group 5. in Groups 2 and 3, decreased COX-2 and TNF-alpha gene expressions were observed when compared with Group 5. Cytochrome c and caspase 3 levels increased in Groups 2 and 3 when compared with Group 5.Conclusion: in conclusion, our results demonstrate that apple extract suppresses rat tongue carcinogenesis as a result of anti-inflammatory activity and apoptosis through the intrinsic mitochondrial pathway. (C) 2014 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/38040
ISSN: 0003-9969
Other Identifiers: http://dx.doi.org/10.1016/j.archoralbio.2014.04.013
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