Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/37894
Title: Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations
Authors: van Os, Jim
Rutten, Bart P.
Myin-Germeys, Inez
Delespaul, Philippe
Viechtbauer, Wolfgang
van Zelst, Catherine
Bruggeman, Richard
Reininghaus, Ulrich
Morgan, Craig
Murray, Robin M.
Di Forti, Marta
McGuire, Philip
Valmaggia, Lucia R.
Kempton, Matthew J.
Gayer-Anderson, Charlotte
Hubbard, Kathryn
Beards, Stephanie
Stilo, Simona A.
Onyejiaka, Adanna
Bourque, Francois
Modinos, Gemma
Tognin, Stefania
Calem, Maria
O'Donovan, Michael C.
Owen, Michael J.
Holmans, Peter
Williams, Nigel
Craddock, Nicholas
Richards, Alexander
Humphreys, Isla
Meyer-Lindenberg, Andreas
Leweke, F. Markus
Tost, Heike
Akdeniz, Ceren
Rohleder, Cathrin
Bumb, J. Malte
Schwarz, Emanuel
Alptekin, Koksal
Ucok, Alp
Saka, Meram Can
Atbasoglu, E. Cem
Guloksuz, Sinan
Gumus-Akay, Guvem
Cihan, Burin
Karadag, Hasan
Soygur, Haldan
Cankurtaran, Eylem Sahin
Ulusoy, Semra
Akdede, Berna
Binbay, Tolga
Ayer, Ahmet
Noyan, Handan
Karadayi, Gulsah
Akturan, Elin
Ulas, Halis
Arango, Celso
Parellada, Mara
Bernardo, Miguel
Sanjuan, Julio
Bobes, Julio
Arrojo, Manuel
Luis Santos, Jose
Cuadrado, Pedro
Rodriguez Solano, Jose Juan
Carracedo, Angel
Garcia Bernardo, Enrique
Roldan, Laura
Lopez, Gonzalo
Cabrera, Bibiana
Cruz, Sabrina
Diaz Mesa, Eva Ma
Pouso, Maria
Jimenez, Estela
Sanchez, Teresa
Rapado, Marta
Gonzalez, Emiliano
Martinez, Covadonga
Sanchez, Emilio
Soledad Olmeda, Ma
Haan, Lieuwe de
Velthorst, Eva
van der Gaag, Mark
Selten, Jean-Paul
van Dam, Daniella
van der Ven, Elsje
van der Meer, Floor
Messchaert, Elles
Kraan, Tamar
Burger, Nadine
Leboyer, Marion
Szoke, Andrei
Schurhoff, Franck
Llorca, Pierre-Michel
Jamain, Stephane
Tortelli, Andrea
Frijda, Flora
Vilain, Jeanne
Galliot, Anne-Marie
Baudin, Gregoire
Ferchiou, Aziz
Richard, Jean-Romain
Bulzacka, Ewa
Charpeaud, Thomas
Tronche, Anne-Marie
De Hert, Marc
van Winkel, Ruud
Decoster, Jeroen
Derom, Catherine
Thiery, Evert
Stefanis, Nikos C.
Sachs, Gabriele
Aschauer, Harald
Lasser, Iris
Winklbaur, Bernadette
Schlogelhofer, Monika
Riecher-Rossler, Anita
Borgwardt, Stefan
Walter, Anna
Harrisberger, Fabienne
Smieskova, Renata
Rapp, Charlotte
Ittig, Sarah
Soguel-Dit-Piquard, Fabienne
Studerus, Erich
Klosterkotter, Joachim
Ruhrmann, Stephan
Paruch, Julia
Julkowski, Dominika
Hilboll, Desiree
Sham, Pak C.
Cherny, Stacey S.
Chen, Eric Y. H.
Campbell, Desmond D.
Li, Miaoxin
Maria Romeo-Casabona, Carlos
Emaldi Cirion, Aitziber
Urruela Mora, Asier
Jones, Peter
Kirkbride, James
Cannon, Mary
Rujescu, Dan
Tarricone, Ilaria
Berardi, Domenico
Bonora, Elena
Seri, Marco
Marcacci, Thomas
Chiri, Luigi
Chierzi, Federico
Storbini, Viviana
Braca, Mauro
Minenna, Maria Gabriella
Donegani, Ivonne
Fioritti, Angelo
La Barbera, Daniele
La Cascia, Caterina Erika
Mule, Alice
Sideli, Lucia
Sartorio, Rachele
Ferraro, Laura
Tripoli, Giada
Seminerio, Fabio
Marinaro, Anna Maria
McGorry, Patrick
Nelson, Barnaby
Amminger, G. Paul
Pantelis, Christos
Menezes, Paulo R.
Del-Ben, Cristina M.
Tenan, Silvia H. Gallo
Shuhama, Rosana
Ruggeri, Mirella
Tosato, Sarah
Lasalvia, Antonio
Bonetto, Chiara
Ira, Elisa
Nordentoft, Merete
Krebs, Marie-Odile
Barrantes-Vidal, Neus
Cristobal, Paula
Kwapil, Thomas R.
Brietzke, Elisa [UNIFESP]
Bressan, Rodrigo A. [UNIFESP]
Gadelha, Ary [UNIFESP]
Maric, Nadja P.
Andric, Sanja
Mihaljevic, Marina
Mirjanic, Tijana
European Network Natl
Maastricht Univ
Kings Coll London
Mondriaan Mental Hlth Trust
Univ Groningen
Cardiff Univ
Cent Inst Mental Hlth
Dokuz Eylul Univ
Istanbul Univ
Ankara Univ
Yale Univ
Middle E Tech Univ
Diskapi YB Res & Training Hosp
Turkish Federat Schizophrenia Assoc
Ataturk Training & Res Hosp
Manisa Mental Hlth Hosp
Univ Complutense
Univ Barcelona
Univ Valencia
Univ Oviedo
Univ Santiago de Compostela
Hosp Virgen de la Luz
Hosp Univ Infanta Leonor Hosp Virgen Torre
Hosp Clin Univ
Hosp Psiquiatr Conxo
Univ Amsterdam
Vrije Univ Amsterdam
EMGO Inst Hlth & Care Res
Parnassia Psychiat Inst
Rivierduinen Psychiat Inst
Grp Hosp Mondor
Hop Henri Mondor
Univ Paris Est
Fdn Fondamental
CMP B CHU
Univ Auvergne
EPS Maison Blanche
UPC KU Leuven
UPC
Katholieke Univ Leuven
Assoc Sci Res Multiple Births
Univ Ghent
Univ Athens
Med Univ Vienna
Psychiat Univ Clin Basel
Univ Cologne
Univ Hong Kong
Univ Basque Country
Univ Zaragoza
Univ Cambridge
UCL
Royal Coll Surgeons Ireland
Univ Munich
Univ Bologna
Local Hlth Trust
Univ Palermo
P Giaccone Gen Hosp
Univ Melbourne
Universidade de São Paulo (USP)
Univ Verona
Copenhagen Univ Hosp
Univ Paris 05
Univ Autonoma Barcelona
St Pere Claver Fundacio Sanitaria
Univ N Carolina
CIBERSAM
Universidade Federal de São Paulo (UNIFESP)
Univ Belgrade
Keywords: schizophrenia
gene-environment interaction
psychosis
epidemiology
genetics
Issue Date: 1-Jul-2014
Publisher: Oxford Univ Press
Citation: Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 40, n. 4, p. 729-736, 2014.
Abstract: Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
URI: http://repositorio.unifesp.br/handle/11600/37894
ISSN: 0586-7614
Other Identifiers: http://dx.doi.org/10.1093/schbul/sbu069
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.