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Title: Antifungal and Cytotoxic 2-Acylcyclohexane-1,3-diones from Peperomia alata and P. trineura
Authors: Ferreira, Edgard A.
Reigada, Juliana B.
Correia, Mauro V.
Young, Maria C. M.
Guimaraes, Elsie F.
Franchi, Gilberto C.
Nowill, Alexandre E.
Lago, Joao H. G. [UNIFESP]
Yamaguchi, Lydia F.
Kato, Massuo J.
Universidade de São Paulo (USP)
Inst Bot
Inst Pesquisa Jardinn Bot Rio de Janeiro
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jun-2014
Publisher: Amer Chemical Soc
Citation: Journal of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 6, p. 1377-1382, 2014.
Abstract: Bioactivity-guided fractionation of the separate CH2Cl2 extracts from the aerial parts of Peperornia alata and P. trineura yielded seven polyketides: alatanone A [3-hydroxy-2-(5'-phenylpent-4'E-enoyl)-cyclohex-2-en-1-one, 1a] and alatanone B [3-hydroxy-2-(3'-phenyl-6'-methylenedioxypropanoyl)cyclohex-2-en-1-one, 2a] from P. alata and trineurone A [3-hydroxy-2-(11'-phenylundec-10'E-enoyl)cyclohex-2-en-1-one, 1b], trineurone B [3-hydroxy-2-(15'-phenyl-18'-methylenedioxy-pentadecanoyl)cyclohex-2-en-1-one, 2b], trineurone C [3-hydroxy-2(17'-phenyl-20'-methylen edioxyheptadecanoyl)cyclohex-2-en-1-one, 2c], trineurone D [3-hydroxy-2-(hexadec-10'Z-enoyl)cyclohex-2-en-1one, 3a], and trineurone E [(6R)-(+)-3,6-dihydroxy-2-(hexadec-10'Zenoyl)cyclohex-2-en-l-one, 3b] from P. trineura. the isolated compounds were evaluated for antifimgal activity against Cladosporium cladosporioides and C. sphaeospermum and for cytotoxicity against the 1(562 and Nalm-6 leukemia cell lines.
ISSN: 0163-3864
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