Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37812
Title: Structural Crystalline Characterization of Sakuranetin - An Antimicrobial Flavanone from Twigs of Baccharis retusa (Asteraceae)
Authors: Grecco, Simone dos S. [UNIFESP]
Dorigueto, Antonio C.
Landre, Iara M.
Soares, Marisi G.
Martho, Kevin [UNIFESP]
Lima, Ricardo [UNIFESP]
Pascon, Renata Castiglioni [UNIFESP]
Vallim, Marcelo Afonso [UNIFESP]
Capello, Tabata M. [UNIFESP]
Romoff, Paulete
Sartorelli, Patricia [UNIFESP]
Lago, Joao Henrique Ghilardi [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Univ Fed Alfenas
Univ Presbiteriana Mackenzie
Keywords: Baccharis retusa
sakuranetin
X-ray diffratometry
antimicrobial activity
Issue Date: 1-Jun-2014
Publisher: Mdpi Ag
Citation: Molecules. Basel: Mdpi Ag, v. 19, n. 6, p. 7528-7542, 2014.
Abstract: Bioactivity-guided fractionation of an antimicrobial active extract from twigs of Baccharis retusa C. DC. (Asteraceae) yielded the flavanone 5,4'-dihydroxy-7-methoxy-flavanone (sakuranetin) as responsible for the detected activity. the structure of the bioactive compound was established on the basis of spectroscopic data analysis, including NMR and MS. Additionally, the structure of a new crystal form of sakuranetin was confirmed by X-ray diffratometry. the minimum inhibitory concentrations (MIC) of isolated compound were determined against pathogenic yeast belonging to the genus Candida (six species), Cryptococcus (two species/four serotypes) and S. cerevisiae BY 4742 (S288c background) and ranged from 0.32 to 0.63 mu g/mu L. Our results showed that sakuranetin, which structure was fully characterized, could be used as a tool for the design of novel and more efficacious antifungal agents.
URI: http://repositorio.unifesp.br/handle/11600/37812
ISSN: 1420-3049
Other Identifiers: http://dx.doi.org/10.3390/molecules19067528
Appears in Collections:Em verificação - Geral

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