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dc.contributor.authorOsuchowski, Marcin F.
dc.contributor.authorRemick, Daniel G.
dc.contributor.authorLederer, James A.
dc.contributor.authorLang, Charles H.
dc.contributor.authorAasen, Ansgar O.
dc.contributor.authorAibiki, Mayuki
dc.contributor.authorAzevedo, Luciano C.
dc.contributor.authorBahrami, Soheyl
dc.contributor.authorBoros, Mihaly
dc.contributor.authorCooney, Robert
dc.contributor.authorCuzzocrea, Salvatore
dc.contributor.authorJiang, Yong
dc.contributor.authorJunger, Wolfgang G.
dc.contributor.authorHirasawa, Hiroyuki
dc.contributor.authorHotchkiss, Richard S.
dc.contributor.authorLi, Xiang-An
dc.contributor.authorRadermacher, Peter
dc.contributor.authorRedl, Heinz
dc.contributor.authorSalomao, Reinaldo [UNIFESP]
dc.contributor.authorSoebandrio, Amin
dc.contributor.authorThiemermann, Christoph
dc.contributor.authorVincent, Jean-Louis
dc.contributor.authorWard, Peter
dc.contributor.authorYao, Yong-Ming
dc.contributor.authorYu, Huang-Ping
dc.contributor.authorZingarelli, Basilia
dc.contributor.authorChaudry, Irshad H.
dc.identifier.citationShock. Philadelphia: Lippincott Williams & Wilkins, v. 41, n. 6, p. 463-475, 2014.
dc.description.abstractMany preclinical studies in critical care medicine and related disciplines rely on hypothesis-driven research in mice. the underlying premise posits that mice sufficiently emulate numerous pathophysiologic alterations produced by trauma/sepsis and can serve as an experimental platform for answering clinically relevant questions. Recently, the lay press severely criticized the translational relevance of mouse models in critical care medicine. A series of provocative editorials were elicited by a highly publicized research report in the Proceedings of the National Academy of Sciences (PNAS; February 2013), which identified an unrecognized gene expression profile mismatch between human and murine leukocytes following burn/trauma/endotoxemia. Based on their data, the authors concluded that mouse models of trauma/inflammation are unsuitable for studying corresponding human conditions. We believe this conclusion was not justified. in conjunction with resulting negative commentary in the popular press, it can seriously jeopardize future basic research in critical care medicine. We will address some limitations of that PNAS report to provide a framework for discussing its conclusions and attempt to present a balanced summary of strengths/weaknesses of use of mouse models. While many investigators agree that animal research is a central component for improved patient outcomes, it is important to acknowledge known limitations in clinical translation from mouse to man. the scientific community is responsible to discuss valid limitations without overinterpretation. Hopefully, a balanced view of the strengths/weaknesses of using animals for trauma/endotoxemia/critical care research will not result in hasty discount of the clear need for using animals to advance treatment of critically ill patients.en
dc.publisherLippincott Williams & Wilkins
dc.rightsAcesso aberto
dc.subjectMouse models of critical illnessen
dc.contributor.institutionAUVA Res Ctr
dc.contributor.institutionBoston Univ
dc.contributor.institutionBrigham & Womens Hosp
dc.contributor.institutionHarvard Univ
dc.contributor.institutionPenn State Coll Med
dc.contributor.institutionOslo Univ Hosp
dc.contributor.institutionEhime Univ
dc.contributor.institutionHosp Sirio Libanes
dc.contributor.institutionUniv Szeged
dc.contributor.institutionSUNY Upstate Med Univ
dc.contributor.institutionUniv Messina
dc.contributor.institutionSouthern Med Univ Guangzhou
dc.contributor.institutionBeth Israel Deaconess Med Ctr
dc.contributor.institutionChiba Univ
dc.contributor.institutionWashington Univ
dc.contributor.institutionUniv Kentucky
dc.contributor.institutionUlm Med Univ Clin
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Indonesia
dc.contributor.institutionQueen Mary Univ London
dc.contributor.institutionUniv Brussels
dc.contributor.institutionUniv Michigan
dc.contributor.institutionChinese Peoples Liberat Army Gen Hosp
dc.contributor.institutionChang Gung Mem Hosp
dc.contributor.institutionCincinnati Childrens Hosp Med Ctr
dc.contributor.institutionUniv Alabama Birmingham
dc.description.affiliationAUVA Res Ctr, Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria
dc.description.affiliationBoston Univ, Sch Med, Boston, MA 02118 USA
dc.description.affiliationBrigham & Womens Hosp, Boston, MA 02115 USA
dc.description.affiliationHarvard Univ, Sch Med, Boston, MA USA
dc.description.affiliationPenn State Coll Med, Hershey, PA USA
dc.description.affiliationOslo Univ Hosp, Oslo, Norway
dc.description.affiliationEhime Univ, Matsuyama, Ehime, Japan
dc.description.affiliationHosp Sirio Libanes, Res & Educ Inst, São Paulo, Brazil
dc.description.affiliationUniv Szeged, Inst Surg Res, Szeged, Hungary
dc.description.affiliationSUNY Upstate Med Univ, Syracuse, NY 13210 USA
dc.description.affiliationUniv Messina, Dept Biol & Environm Sci, Messina, Italy
dc.description.affiliationSouthern Med Univ Guangzhou, Guangzhou, Guangdong, Peoples R China
dc.description.affiliationBeth Israel Deaconess Med Ctr, Boston, MA 02215 USA
dc.description.affiliationChiba Univ, Grad Sch Med, Chiba, Japan
dc.description.affiliationWashington Univ, Sch Med, St Louis, MO USA
dc.description.affiliationUniv Kentucky, Coll Med, Lexington, KY USA
dc.description.affiliationUlm Med Univ Clin, Ulm, Germany
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Hosp São Paulo, Div Infect Dis,Dept Med, São Paulo, Brazil
dc.description.affiliationUniv Indonesia, Jakarta, Indonesia
dc.description.affiliationQueen Mary Univ London, William Harvey Res Inst, London, England
dc.description.affiliationUniv Brussels, Erasme Univ Hosp, Brussels, Belgium
dc.description.affiliationUniv Michigan, Sch Med, Ann Arbor, MI USA
dc.description.affiliationChinese Peoples Liberat Army Gen Hosp, Hosp 1, Burns Inst, Beijing, Peoples R China
dc.description.affiliationChang Gung Mem Hosp, Taipei 10591, Taiwan
dc.description.affiliationCincinnati Childrens Hosp Med Ctr, Div Crit Care Med, Cincinnati, OH 45229 USA
dc.description.affiliationUniv Alabama Birmingham, Birmingham, AL 35294 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Hosp São Paulo, Div Infect Dis,Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
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