|Title: ||Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil|
|Authors: ||Gomes, Marilia Brito|
Negrato, Carlos Antonio
Monteiro Tannus, Lucianne Righeti
Goncalves, Paolla Ribeiro
Barreto da Silva, Pedro Carlos
Ivar Carneiro, Joao Regis
Mattos Matheus, Alessandra Saldanha
Dib, Sergio Atala [UNIFESP]
Azevedo, Mirela Jobim
Nery, Marcia [UNIFESP]
Montenegro Junior, Renan Magalhaes
Calliari, Luis Eduardo
Luescher, Jorge L.
Berardo, Renata S.
Arruda-Marques, Maria Carmo [UNIFESP]
Noronha, Renata M.
Manna, Thais D.
Penha, Fernanda G.
Foss, Milton C.
Foss-Freitas, Maria C.
Pires, Antonio C.
Robles, Fernando C.
Guedes, Maria de Fatima S.
Dualib, Patricia [UNIFESP]
Silva, Saulo C.
Faria, Ana Cristina R.
Canani, Luis Henrique
Zucatti, Alessandra T.
Coral, Marisa Helena C.
Pereira, Daniela Aline
Araujo, Luiz Antonio
Pedrosa, Hermelinda C. [UNIFESP]
Prado, Flaviane A. [UNIFESP]
Araujo, Leticia B.
Fonseca, Reine Marie C.
Guedes, Alexis D.
Matos, Odelissa S.
Palma, Catia C.
Forti, Adriana C.
Montenegro, Ana Paula
Melo, Naira H.
Rezende, Karla F.
Felicio, Joao Soares
Santos, Flavia M.
Brazilian Type 1 Diabetes Study Group
Universidade do Estado do Rio de Janeiro (UERJ)
Baurus Diabet Assoc
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Hosp Porto Alegre
Universidade Federal do Rio de Janeiro (UFRJ)
Univ Fed Ceara
Santa Casa Misericordia
Santa Casa Misericordia São Paulo
Univ Fed Amazonas
Hosp Geral de Bonsucesso
Hosp Univ Clementino Fraga Filho IPPMG
Fac Ciencias Med Santa Casa São Paulo
Universidade de São Paulo (USP)
Ambulatorio Fac Estadual Med Sao Jose Rio Preto
Clin Endocrinol Santa Casa Belo Horizonte
Universidade Estadual de Londrina (UEL)
Univ Fed Parana
Inst Crianca Com Diabet Rio Grande Sul
Grp Hosp Conceicao
Hosp Univ Santa Catarina
Inst Diabet Endocrinol Joinville
Hosp Reg Taguatinga
Hosp Geral Goiania
Ctr Diabet & Endocrinol Estado Bahia
Univ Fed Maranhao
Ctr Integrado Diabet & Hipertensao Ceara
Univ Fed Sergipe
Hosp Univ Alcides Carneiro
Hosp Univ Joao de Barros Barreto
|Keywords: ||Type 1 diabetes|
|Issue Date: ||31-May-2014|
|Publisher: ||Biomed Central Ltd|
|Citation: ||Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 9 p., 2014.|
|Abstract: ||Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D).Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups.Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). the majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001).Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits.|
|Other Identifiers: ||http://dx.doi.org/10.1186/1758-5996-6-67|
|Appears in Collections:||Em verificação - Geral|
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