Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37789
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorCirilo, Priscila Daniele Ramos[UNIFESP]
dc.contributor.authorMazzotti, Tatiane Katsue Furuya [UNIFESP]
dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorWisnieski, Fernanda [UNIFESP]
dc.contributor.authorDemachki, Samia
dc.contributor.authorMartinez, Margarita Cortes [UNIFESP]
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorChammas, Roger [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorSmith, Marilia Cardoso [UNIFESP]
dc.date.accessioned2016-01-24T14:37:19Z-
dc.date.available2016-01-24T14:37:19Z-
dc.date.issued2014-05-30
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0098583
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 5, 9 p., 2014.
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37789-
dc.description.abstractPHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. the T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent9
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleProhibitin Expression Deregulation in Gastric Cancer Is Associated with the 3 ' Untranslated Region 1630 C > T Polymorphism and Copy Number Variationen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Canc Estado São Paulo
dc.contributor.institutionFed Univ Para
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Med, Dept Radiol, Lab Oncol Expt, São Paulo, Brazil
dc.description.affiliationInst Canc Estado São Paulo, Ctr Invest Translat Oncol, São Paulo, Brazil
dc.description.affiliationFed Univ Para, Hosp Univ Joao Barros Barreto, BR-66059 Belem, Para, Brazil
dc.description.affiliationFed Univ Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66059 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Med, Dept Radiol, Lab Oncol Expt, São Paulo, Brazil
dc.identifier.fileWOS000338101500069.pdf
dc.identifier.doi10.1371/journal.pone.0098583
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000338101500069
Appears in Collections:Em verificação - Geral

Files in This Item:
File Description SizeFormat 
WOS000338101500069.pdf4.02 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.