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Title: Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3 ' Untranslated Region 1630 C > T Polymorphism and Copy Number Variation
Authors: Leal, Mariana Ferreira [UNIFESP]
Cirilo, Priscila Daniele Ramos[UNIFESP]
Mazzotti, Tatiane Katsue Furuya [UNIFESP]
Calcagno, Danielle Queiroz [UNIFESP]
Wisnieski, Fernanda [UNIFESP]
Demachki, Samia
Martinez, Margarita Cortes [UNIFESP]
Assumpcao, Paulo Pimentel
Chammas, Roger [UNIFESP]
Burbano, Rommel Rodriguez
Smith, Marilia Cardoso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Inst Canc Estado São Paulo
Fed Univ Para
Issue Date: 30-May-2014
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 9, n. 5, 9 p., 2014.
Abstract: PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. the T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.
ISSN: 1932-6203
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