Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37762
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCorbi, Fernanda Cristina [UNIFESP]
dc.contributor.authorOliveira, Mariana Bleker de [UNIFESP]
dc.contributor.authorMorelli, Vania M. [UNIFESP]
dc.contributor.authorHan, Sang W. [UNIFESP]
dc.contributor.authorRenauld, Jean-Christophe
dc.contributor.authorKnoops, Laurent
dc.contributor.authorColleoni, Gisele Wally Braga [UNIFESP]
dc.date.accessioned2016-01-24T14:37:17Z
dc.date.available2016-01-24T14:37:17Z
dc.date.issued2014-05-01
dc.identifierhttp://dx.doi.org/10.3109/10428194.2013.828352
dc.identifier.citationLeukemia & Lymphoma. London: Informa Healthcare, v. 55, n. 5, p. 1176-1180, 2014.
dc.identifier.issn1042-8194
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37762
dc.description.abstractConsidering the recent impact of tyrosine kinase inhibitors in the treatment of myeloproliferative disorders carrying a recurrent JAK2 mutation not identified in multiple myeloma (MM), this study aimed to search for mutations in kinase and pseudokinase domains of the JAK1 gene in an attempt to define any critical and recurring change that can be used as a therapeutic target. We obtained CD138 + purified cells from 27 bone marrow aspirates of untreated MM, four normal controls and four MM cell lines. After amplification of kinase and pseudokinase domains of JAK1 in cDNA samples, the fragments were automatically sequenced. Seventy-eight percent of MM cases showed at least one polymorphism, all being synonymous single nucleotide polymorphisms (SNPs), with allele frequencies consistent with previous studies in normal European, African American and Asian populations. the four cell lines also showed only synonymous SNPs. Mutations in the kinase and pseudokinase domains of the JAK1 gene do not seem to be important for activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway because we were not able to find any recurrent mutation in a case series of 27 patients and four MM cell lines.en
dc.format.extent1176-1180
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofLeukemia & Lymphoma
dc.rightsAcesso restrito
dc.subjectMultyple myelomaen
dc.subjectJAK/STATen
dc.subjectJAK1en
dc.subjectmutationen
dc.titleActivation of the Janus kinase/signal transducer and activator of transcription pathway in multiple myeloma is not related to point mutations in kinase and pseudokinase domains of JAK1en
dc.typeArtigo
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionCatholic Univ Louvain
dc.contributor.institutionClin Univ St Luc
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, BR-04037003 São Paulo, Brazil
dc.description.affiliationLudwig Inst Canc Res, Brussels, Belgium
dc.description.affiliationCatholic Univ Louvain, Duve Inst, Brussels, Belgium
dc.description.affiliationClin Univ St Luc, Hematol Unit, Brussels, Belgium
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, BR-04037003 São Paulo, Brazil
dc.identifier.doi10.3109/10428194.2013.828352
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000335217100032
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.