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Title: Is there any relationship between gene expression of tumor antigens and CD4(+) T cells in multiple myeloma?
Authors: Braga, Walter M. T.
Silva, Bruna R. da [UNIFESP]
Alves, Veruska L. F. [UNIFESP]
Bortoluzo, Adriana B.
Atanackovic, Djordje
Colleoni, Gisele W. B. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Insper Inst Educ & Res
Univ Med Ctr Hamburg Eppendorf
Keywords: cancer/testis antigen
multiple myeloma
Issue Date: 1-May-2014
Publisher: Future Medicine Ltd
Citation: Immunotherapy. London: Future Medicine Ltd, v. 6, n. 5, p. 569-575, 2014.
Abstract: Aim: the present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.
ISSN: 1750-743X
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