Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37738
Title: Selenium inadequacy is not associated with oxidative stress in child and adolescent acute lymphocytic leukemia survivors
Authors: Sousa Almondes, Kaluce Goncalves de
Oliveira, Tiago Franco de
Siviero-Miachon, Adriana Aparecida [UNIFESP]
Martino Lee, Maria Lucia de [UNIFESP]
Carvalho Rondo, Patricia Helen de
Melo Loureiro, Ana Paula de
Spinola-Castro, Angela Maria [UNIFESP]
Franciscato Cozzolino, Silvia Maria
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Acute lymphoblastic leukemia
Selenium
Oxidative stress
Antioxidants
DNA damage
Chemotherapy
Issue Date: 1-May-2014
Publisher: Elsevier B.V.
Citation: Nutrition. New York: Elsevier B.V., v. 30, n. 5, p. 563-568, 2014.
Abstract: Objective: Acute lymphocytic leukemia (ALL) and its subsequent treatment may provoke increased oxidative stress. the aim of this study was to investigate the antioxidant status of children and adolescents who had received ALL therapy, and to test the hypothesis that selenium (Se) inadequacy is correlated with reduced defenses against oxidative stress in this population.Methods: This case-control study involved 24 patients between ages 5 and 13 y who had been treated successfully for ALL (ALL group) and 60 children of similar age and socioeconomic background with no clinical history of leukemia (control group). Dietary intake of Se was evaluated by the 24-h recall method, and the concentrations of Se in plasma, erythrocytes, and urine determined. Antioxidant status was assessed by analysis of the oxidative stress markers, namely, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), alpha-tocopherol, and 8-oxo-deoxyguanosine (8-oxo-dG).Results: There were no between-group differences with respect to plasma (P = 0.122), erythrocyte (P = 0.202), urinary (P = 0.608), or dietary (P = 0.757) levels of Se. GPx activity was significantly (P < 0.001) reduced in the ALL group compared with the control group, whereas SOD activity and MDA concentrations were similar. the concentrations of alpha-tocopherol and 8-oxo-dG were significantly increased in the ALL group compared with the control group (P < 0.001 and P = 0.031, respectively).Conclusion: All participants were Se inadequate, but such inadequacy was not correlated with reduced defenses against oxidative stress. However, individuals of the ALL group were with increased oxidative stress compared with the control group, possibly due to previous disease and to intensive polychemotherapy. (C) 2014 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/37738
ISSN: 0899-9007
Other Identifiers: http://dx.doi.org/10.1016/j.nut.2013.10.012
Appears in Collections:Em verificação - Geral

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