Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37722
Title: Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil
Authors: Soares de Araujo, Rubistenia Miranda
Vieira de Melo, Cynthia Farias
Manes Neto, Fidelis
Silva, Juarez Nobrega da
Soares, Leonardo Ferreira
Cardoso Smith, Marilia de Arruda [UNIFESP]
Sousa, Edilson Carvalho
Rodriguez Burbano, Rommel Mario
Medeiros, Arnaldo Correia de
Lima, Eleonidas Moura
Universidade Federal da Paraíba (UFPB)
Hosp Sao Marcos
State Univ Paraiba UEPB
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Keywords: SNPs
Gastric cancer
GSTP1
Issue Date: 1-May-2014
Publisher: Springer
Citation: Tumor Biology. Dordrecht: Springer, v. 35, n. 5, p. 4983-4986, 2014.
Abstract: Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. the results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher's exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (chi (2) = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.
URI: http://repositorio.unifesp.br/handle/11600/37722
ISSN: 1010-4283
Other Identifiers: http://dx.doi.org/10.1007/s13277-014-1656-z
Appears in Collections:Em verificação - Geral

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