Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/37666
Title: Usefulness of the SYNTAX Score to Predict Acute Kidney Injury After Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage Strategy Trial)
Authors: Madhavan, Mahesh V.
Genereux, Philippe
Rubin, Jonah
Palmerini, Tullio
Caixeta, Adriano [UNIFESP]
Xu, Ke
Weisz, Giora
Mehran, Roxana
Stone, Gregg W.
NewYork Presbyterian Hosp
Columbia Univ
Cardiovasc Res Fdn
Univ Montreal
Univ Bologna
Universidade Federal de São Paulo (UNIFESP)
Mt Sinai Med Ctr
Issue Date: 15-Apr-2014
Publisher: Elsevier B.V.
Citation: American Journal of Cardiology. Bridgewater: Excerpta Medica Inc-Elsevier B.V., v. 113, n. 8, p. 1331-1337, 2014.
Abstract: The synergy between percutaneous coronary intervention (PCI) with Taxus and cardiac surgery (SYNTAX) score (SS) has prognostic utility for ischemic outcomes in patients undergoing PCI. Acute kidney injury (AKI) after PCI has been demonstrated to be associated with adverse outcomes. However, the relation between the SS and AKI after PCI has yet to be fully investigated. We therefore sought to study this relation in the formal angiographic substudy of the large Acute Catheterization and Urgent Intervention Triage Strategy trial. We stratified 2,268 patients who underwent PCI for non-ST-segment elevation acute coronary syndromes by postprocedural AKI status and by SS tertiles (SS <7,7 to 12, and >12). We also assessed rates of in-hospital, 30-day, and 1-year adverse outcomes. A total of 226 patients (10%) developed AKI, and rates in the highest Acute Catheterization and Urgent Intervention Triage Strategy SS tertile (>12) were significantly greater than those in the intermediate (7 to 12) and lowest tertiles (<7; 13% vs 8.9% vs 7.7%, respectively, p = 0.002). By multivariable analysis, the SS was independently associated with AKI (odds ratio per 10 SS points 1.22,95% confidence interval 1.04 to 1.43, p = 0.02. Rates of major adverse cardiovascular events and net adverse clinical events increased significantly by SS tertile and were more common in patients who developed.AKI. Patients who developed AKI experienced higher in-hospital, 30-day, and 1-year rates of mortality. in this large study, the SS was independently associated with AKI after PCI for non-ST-segment elevation acute coronary syndromes, and patients who developed AKI experienced worse short-term and long-term outcomes. (C) 2014 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/37666
ISSN: 0002-9149
Other Identifiers: http://dx.doi.org/10.1016/j.amjcard.2013.12.041
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