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Title: Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network
Authors: Ferreira, Adilson Kleber
de-Sa-Junior, Paulo Luiz
Pasqualoto, Kerly Fernanda Mesquita
Azevedo, Ricardo Alexandre de
Dias Camara, Diana Aparecida
Costa, Andre Santos
Figueiredo, Carlos Rogerio [UNIFESP]
Matsuo, Alisson Leonardo [UNIFESP]
Massaoka, Mariana Hiromi [UNIFESP]
Vatti Auada, Aline Vivian
Lebrun, Ivo
Costa Bernstorff Damiao, Mariana Celestina Frojuello
Tavares, Mauricio Temotheo
Motter Magri, Fatima Maria
Kerkis, Irina
Parise Filho, Roberto
Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Prebiteriana Mackenzie
Keywords: Piper aduncum
Cell cycle
Molecular modeling
Issue Date: 1-Apr-2014
Publisher: Elsevier B.V.
Citation: Biochimie. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 99C, p. 195-207, 2014.
Abstract: Breast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. the use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Here, we have demonstrated for the first time that dillapiole has broad cytotoxic effects against a variety tumor cells. for instance, we found that it can act as a pro-oxidant compound through the induction of reactive oxygen species (ROS) release in MDA-MB-231 cells. We also demonstrated that dillapiole exhibits antiproliferative properties, arresting cells at the G0/G1 phase and its antimigration effects can be associated with the disruption of actin filaments, which in turn can prevent tumor cell proliferation. Molecular modeling studies corroborated the biological findings and suggested that dillapiole may present a good pharmacokinetic profile, mainly because its hydrophobic character, which can facilitate its diffusion through tumor cell membranes. All these findings support the fact that dillapiole is a promising anticancer agent. (C) 2013 Elsevier Masson SAS. All rights reserved.
ISSN: 0300-9084
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