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Title: Cytogenetic biomonitoring of oral mucosa cells of crack cocaine users
Authors: Alonso de Oliveira, Maria das Gracas
Santos, Jean Nunes dos
Cury, Patricia Ramos
Pereira da Silva, Victor Hugo [UNIFESP]
Cruz Oliveira, Nara Rejane [UNIFESP]
Padovani, Ricardo da Costa [UNIFESP]
Tucci, Adriana Marcassa [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Univ Fed Bahia
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Apr-2014
Publisher: Springer
Citation: Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 8, p. 5760-5764, 2014.
Abstract: The aim of the present study was to comparatively evaluate genomic damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated oral mucosa cells from crack cocaine users by micronucleus test. A total of 30 crack cocaine users and 30 health controls (non-exposed individuals) were included in this setting. Individuals had epithelial cells from cheek mechanically exfoliated, placed in fixative, and dropped in clean slides, which were checked for the above nuclear phenotypes. the results pointed out significant statistical differences (p < 0.05) of micronucleated oral mucosa cells from crack cocaine users. Exposure to crack cocaine caused an increase of other nuclear alterations closely related to cytotoxicity such as karyolysis in oral cells as well. in summary, these data indicate that crack cocaine is able to induce chromosomal breakage and cellular death in oral mucosa cells of users.
ISSN: 0944-1344
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