Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37548
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dc.contributor.authorSilva, Jose Antonio
dc.contributor.authorSantana, Eduardo Tadeu
dc.contributor.authorManchini, Martha Trindade
dc.contributor.authorAntonio, Ednei Luis [UNIFESP]
dc.contributor.authorBocalini, Danilo Sales
dc.contributor.authorKrieger, Jose Eduardo
dc.contributor.authorTucci, Paulo José Ferreira [UNIFESP]
dc.contributor.authorSerra, Andrey Jorge
dc.date.accessioned2016-01-24T14:35:26Z-
dc.date.available2016-01-24T14:35:26Z-
dc.date.issued2014-03-10
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0091017
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 3, 9 p., 2014.
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37548-
dc.description.abstractSympathetic hyperactivity induces adverse effects in myocardial. Recent studies have shown that exercise training induces cardioprotection against sympathetic overload; however, relevant mechanisms of this issue remain unclear. We analyzed whether exercise can prevent pathological hypertrophy induced by sympathetic hyperactivity with modulation of the kallikrein-kinin and angiogenesis pathways. Male Wistar rats were assigned to non-trained group that received vehicle; non-trained isoproterenol treated group (Iso, 0.3 mg kg(-1) day(-1)); and trained group (Iso+Exe) which was subjected to sympathetic hyperactivity with isoproterenol. the Iso rats showed hypertrophy and myocardial dysfunction with reduced force development and relaxation of muscle. the isoproterenol induced severe fibrosis, apoptosis and reduced myocardial capillary. Interestingly, exercise blunted hypertrophy, myocardial dysfunction, fibrosis, apoptosis and capillary decreases. the sympathetic hyperactivity was associated with high abundance of ANF mRNA and beta-MHC mRNA, which was significantly attenuated by exercise. the tissue kallikrein was augmented in the Iso+Exe group, and kinin B-1 receptor mRNA was increased in the Iso group. Moreover, exercise induced an increase of kinin B-2 receptor mRNA in myocardial. the myocardial content of eNOS, VEGF, VEGF receptor 2, pAkt and Bcl-2 were increased in the Iso+Exe group. Likewise, increased expression of pro-apoptotic Bad in the Iso rats was prevented by prior exercise. Our results represent the first demonstration that exercise can modulate kallikrein-kinin and angiogenesis pathways in the myocardial on sympathetic hyperactivity. These findings suggest that kallikrein-kinin and angiogenesis may have a key role in protecting the heart.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipNational Council for Scientific and Technological
dc.format.extent9
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleExercise Training Can Prevent Cardiac Hypertrophy Induced by Sympathetic Hyperactivity with Modulation of Kallikrein-Kinin Pathway and Angiogenesisen
dc.typeArtigo
dc.contributor.institutionUniv Nove Julho Uninove
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Nove Julho Uninove, Programa Posgrad Ciencias Reabilitacao, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Nove Julho Uninove, Programa Posgrad Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2009/54225-8
dc.description.sponsorshipIDNational Council for Scientific and Technological: 477458/2009-2
dc.description.sponsorshipIDNational Council for Scientific and Technological: 479395/2012-8
dc.identifier.fileWOS000332839300064.pdf
dc.identifier.doi10.1371/journal.pone.0091017
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000332839300064
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