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Title: HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control
Authors: Pinto, Camila S. [UNIFESP]
Lana, Janaina M. [UNIFESP]
Gabbay, Monica Andrade Lima [UNIFESP]
Sa, Joao R. de [UNIFESP]
Dib, Sergio A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: high-density lipoprotein (HDL) cholesterol
carotid intima-media thickness
Type 1 diabetes
Issue Date: 1-Mar-2014
Publisher: Sage Publications Ltd
Citation: Diabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 11, n. 2, p. 125-128, 2014.
Abstract: The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 +/- 4.0 years, disease duration 9.8 +/- 4.8 years) and for 36 matched healthy subjects. Considering all the participants as one group, male sex (p = 0.008), weight (p = 0.016) and T1D (p < 0.001) were positively associated with a higher cIMT. High-density lipoprotein (HDL) (p = 0.036) was negatively associated with cIMT in T1D. in the male T1D patients, HDL <= 47.5 mg/dL had a sensitivity of 87.5% and specificity of 57% (p = 0.035) in detecting those belonging to a higher cIMT tercile. in conclusion, weight and T1D were associated with increased cIMT. HDL levels <= 47.5 mg/dL were related to a higher cIMT in male T1D patients.
ISSN: 1479-1641
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