Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37431
Title: Memory Networks in Tinnitus: A Functional Brain Image Study
Authors: Laureano, Maura Regina [UNIFESP]
Onishi, Ektor Tsuneo [UNIFESP]
Bressan, Rodrigo Affonseca [UNIFESP]
Castiglioni, Mario Luiz Vieira [UNIFESP]
Batista, Ilza Rosa [UNIFESP]
Reis, Marilia Alves [UNIFESP]
Garcia, Michele Vargas [UNIFESP]
Andrade, Adriana Neves de [UNIFESP]
Almeida, Roberta Ribeiro de [UNIFESP]
Garrido, Griselda J.
Jackowski, Andrea Parolin [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Univ Western Australia
Issue Date: 6-Feb-2014
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 9, n. 2, 5 p., 2014.
Abstract: Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. the network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. the objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). the severity of tinnitus was assessed using the Tinnitus Handicap Inventory (THI). the images were processed and analyzed using Statistical Parametric Mapping (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE<0.05) was observed in patients with tinnitus compared with healthy controls. the average total THI score was 50.8+18.24, classified as moderate tinnitus. Conclusion: It was possible to identify significant changes in the limbic system of the brain perfusion in tinnitus patients with normal hearing, suggesting that central mechanisms, not specific to the auditory pathway, are involved in the pathophysiology of symptoms, even in the absence of clinically diagnosed peripheral changes.
URI: http://repositorio.unifesp.br/handle/11600/37431
ISSN: 1932-6203
Other Identifiers: http://dx.doi.org/10.1371/journal.pone.0087839
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.