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dc.contributor.authorRabinowitz, Yaron S.
dc.contributor.authorLi, Xiaohui
dc.contributor.authorCaiado Canedo, Ana Laura
dc.contributor.authorAmbrosio, Renato [UNIFESP]
dc.contributor.authorBykhovskaya, Yelena
dc.identifier.citationJournal of Refractive Surgery. Thorofare: Slack Inc, v. 30, n. 2, p. 80-+, 2014.
dc.description.abstractPURPOSE: To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus.METHODS: Videokeratography, wavefront analysis, and measured OCT indices were performed on 180 normal eyes, 46 eyes with moderate keratoconus, 54 eyes with early keratoconus, 7 eyes with forme fruste keratoconus, and 16 eyes with keratoconus suspect to determine the most sensitive parameters for separating these groups.RESULTS: A combination of videokeratography and OCT indices (inferior-superior [I-S] value and minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normal eyes (P < .001). Using a newly derived index, the minimum pachymetry divided by the I-S value (pachymetry/asymmetry [PA]/I-S index) with a cut-off of 100, 100% of early and forme fruste keratoconus could be identified as being abnormal with 7 normals misclassified (misclassification rate 2.7%). By adding keratoconus suspect to the analysis and an I-S value of 1.2 as a cut-off point, 5 suspects were classified as normal and 11 normals as abnormal (misclassification rate 7.8%). the PA/I-S index, with a cut-off point of 100, reduced this misclassification rate to 4.4%.CONCLUSIONS: These results suggest that OCT combined with videokeratography may be more useful for differentiating mild forms of keratoconus than videokeratography alone.en
dc.description.sponsorshipNational Eye Institutes of Health
dc.description.sponsorshipSkirball Foundation for Molecular Ophthalmology, Los Angeles, California
dc.description.sponsorshipEye Defects Research Foundation Inc., Beverly Hills, California
dc.publisherSlack Inc
dc.relation.ispartofJournal of Refractive Surgery
dc.rightsAcesso restrito
dc.titleOptical Coherence Tomography Combined With Videokeratography to Differentiate Mild Keratoconus Subtypesen
dc.contributor.institutionCornea Genet Eye Inst
dc.contributor.institutionCedars Sinai Med Ctr
dc.contributor.institutionHarbor UCLA Med Ctr
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionInst Olhos Renato Ambrosio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationCornea Genet Eye Inst, Beverly Hills, CA USA
dc.description.affiliationCedars Sinai Med Ctr, Regenerat Med Inst, Los Angeles, CA 90048 USA
dc.description.affiliationHarbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA
dc.description.affiliationUniv Calif Los Angeles, Jules Stein Eye Inst, Los Angeles, CA 90024 USA
dc.description.affiliationInst Olhos Renato Ambrosio, Rio de Janeiro, Brazil
dc.description.affiliationUniv São Paulo, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniv São Paulo, UNIFESP, São Paulo, Brazil
dc.description.sponsorshipIDNational Eye Institutes of Health: NEI-RO1-09052
dc.description.sourceWeb of Science
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