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Title: Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells
Authors: Machado-Neto, Joao Agostinho
Campos, Paula de Melo
Favaro, Patricia [UNIFESP]
Lazarini, Mariana
Lorand-Metze, Irene
Costa, Fernando Ferreira
Olalla Saad, Sara Teresinha
Traina, Fabiola
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Stathmin 1
Myelodysplastic syndromes
Acute myeloid leukemia
Acute lymphoid leukemia
Issue Date: 1-Feb-2014
Publisher: Elsevier B.V.
Citation: Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 38, n. 2, p. 251-257, 2014.
Abstract: Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. in addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies. (C) 2013 Elsevier B.V. All rights reserved.
ISSN: 0145-2126
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