Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37367
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dc.contributor.authorVieira de Melo, Cynthia Farias
dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorSilva, Juarez Nobrega da
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.authorAraujo, Rubistenia Miranda de
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorLima, Eleonidas Moura
dc.date.accessioned2016-01-24T14:35:13Z-
dc.date.available2016-01-24T14:35:13Z-
dc.date.issued2014-02-01
dc.identifierhttp://dx.doi.org/10.1007/s13277-013-1148-6
dc.identifier.citationTumor Biology. Dordrecht: Springer, v. 35, n. 2, p. 1107-1111, 2014.
dc.identifier.issn1010-4283
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37367-
dc.description.abstractTo verify the methylation status of THBS1, GPX3, and COX2 genes and to evaluate their association with Helicobacter pylori in gastric adenocarcinomas. Methylation-sensitive restriction enzyme PCR assay was performed in 16 diffuse type gastric cancer samples, 23 intestinal type, and 15 normal stomach tissue. the presence of H. pylori was performed by amplification of the fragment of the 16S rRNA. Statistical analyses were performed using Fisher's exact test. the hypermethylation of GPX3, THBS1, and COX2 occurred in 18 (n = 7), 5 (n = 2), and 36 % (n = 14) of gastric cancer samples, respectively, whereas in normal samples, it was found in 13, 7, and 67 %. the presence of H. pylori was detected in 67 % of gastric cancer samples and 67 % in normal gastric samples. the methylation of THBS1 and GPX3 was not significantly different between the types of tumors, normal sample, the presence of H. pylori, or clinicopathological variables studied (P > 0.05). However, the methylation status of the gene COX2 is significantly different between normal tissue and intestinal type gastric cancer (P = 0.02). Therefore, our results suggest that the methylation status of the gene COX2 is associated with the intestinal type of gastric cancer.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1107-1111
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTumor Biology
dc.rightsAcesso restrito
dc.subjectGastric canceren
dc.subjectMethylationen
dc.subjectCOX2en
dc.titleAssociation of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazilen
dc.typeArtigo
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institutionUniv Fed Paraiba
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.description.affiliationUniv Fed Paraiba, Grad Program Cellular & Mol Biol, Dept Mol Biol, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Lab Struct Mol Biol & Oncogenet LBMEO, Dept Mol Biol, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, CCEN, Dept Mol Biol, Lab Struct Mol Biol & Oncogenet LBMEO, BR-58051900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Ctr Biol Sci, Dept Biol, BR-66075110 Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1007/s13277-013-1148-6
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000332026300032
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