Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/37351
Title: The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents
Other Titles: La dieta de alto índice glucémico es un predictor independiente para explicar los cambios en la proteína relacionada al agouti en adolescentes obesos
Authors: Dal Molin Netto, Barbara [UNIFESP]
Masquio, Deborah Cristina Landi [UNIFESP]
Campos, Raquel Munhoz da Silveira [UNIFESP]
Sanches, Priscila de Lima [UNIFESP]
Corgosinho, Flavia Campos [UNIFESP]
Tock, Lian
Oyama, Lila Missae [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Tufik, Sergio [UNIFESP]
Damaso, Ana Raimunda [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Obesity
Energy balance
Neuropeptides
Food consumption
Glycemic index
Issue Date: 1-Feb-2014
Publisher: Aula Medica Ediciones
Citation: Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 29, n. 2, p. 305-314, 2014.
Abstract: The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.Background & Aims: the role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy balance is still not clear. the present study aimed to assess whether the habitual diet, according to different GI foods, exerts influence on regulation of energy balance markers and the effects of interdisciplinary intervention in obese adolescents.Methods: A total of 55 obese adolescents, aged from 14 to 19 years, were submited to one year of interdisciplinary therapy and were divided in two groups, according to the predominant dietary pattern of food intake: high-GI group (H-GI; n = 29) and moderate/low-GI group (M/L-GI; n = 26).Results: the concentration of orexigenic factor AgRP (p < 0.01), visceral fat (p = 0.04) and visceral/subcutaneous ratio (p = 0.03) were higher in the group of H-GI when compared with M/L-GI group. Moreover, the habitual consumption of H-GI foods was an independent predictor to explain changes in AgRP concentrations. After one year of interdisciplinary therapy, the adolescents presented significant reductions in body weight, total body fat (%), visceral and subcutaneous fat and HOMA-IR, as well as a significant increase of fat free mass (%).Conclusions: Our results may suggest that habitual H-GI diet could upregulate orexigenic pathways, contributing to vicious cycle between undesirable diets, deregulates energy balance and predispose to obesity. One the other hand, one year of interdisciplinary therapy can significant improves metabolic profile and central obesity in adolescents.
URI: http://repositorio.unifesp.br/handle/11600/37351
ISSN: 0212-1611
Other Identifiers: http://dx.doi.org/10.3305/nh.2014.29.2.7087
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