Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37249
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dc.contributor.authorMarta, Gustavo Nader
dc.contributor.authorSilva, Valter [UNIFESP]
dc.contributor.authorCarvalho, Heloisa de Andrade
dc.contributor.authorArruda, Fernando Freire de
dc.contributor.authorHanna, Samir Abdallah
dc.contributor.authorGadia, Rafael
dc.contributor.authorFernandes da Silva, Joao Luis
dc.contributor.authorMiranda Correa, Sebastiao Francisco
dc.contributor.authorCintra Vita Abreu, Carlos Eduardo
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.date.accessioned2016-01-24T14:35:04Z-
dc.date.available2016-01-24T14:35:04Z-
dc.date.issued2014-01-01
dc.identifierhttp://dx.doi.org/10.1016/j.radonc.2013.11.010
dc.identifier.citationRadiotherapy and Oncology. Clare: Elsevier B.V., v. 110, n. 1, p. 9-15, 2014.
dc.identifier.issn0167-8140
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37249-
dc.description.abstractBackground and purpose: Intensity-modulated radiation therapy (IMRT) provides the possibility of dose-escalation with better normal tissue sparing. This study was performed to assess whether IMRT can improve clinical outcomes when compared with two-dimensional (2D-RT) or three-dimensional conformal radiation therapy (3D-CRT) in patients with head and neck cancer.Methods and materials: Only prospective phase III randomized trials comparing IMRT with 2D-RT or 3D-CRT were eligible. Combined surgery and/or chemotherapy were allowed. Two authors independently selected and assessed the studies regarding eligibility criteria and risk of bias.Results: Five studies were selected. A total of 871 patients were randomly assigned for 2D-RT or 3D-CRT.(437), versus IMRT (434). Most patients presented with nasopharyngeal cancers (82%), and stages III/IV (62.1%). Three studies were classified as having unclear risk and two as high risk of bias. A significant overall benefit in favor of IMRT was found (hazard ratio - HR = 0.76; 95% CI: 0.66, 0.87; p < 0.0001) regarding xerostomia scores grade 2-4, with similar loco-regional control and overall survival.Conclusions: IMRT reduces the incidence of grade 2-4 xerostomia in patients with head and neck cancers without compromising loco-regional control and overall survival. (C) 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 110 (2014) 9-15en
dc.format.extent9-15
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRadiotherapy and Oncology
dc.rightsAcesso restrito
dc.subjectHead and neck canceren
dc.subjectIntensity-modulated radiation therapyen
dc.subjectTwo-dimensionalen
dc.subjectThree-dimensional conformal radiation therapyen
dc.titleIntensity-modulated radiation therapy for head and neck cancer: Systematic review and meta-analysisen
dc.typeResenha
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionHosp Sirio Libanes
dc.contributor.institutionInst Canc São Paulo ICESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationHosp Sirio Libanes, Dept Radiat Oncol, BR-01308050 São Paulo, SP, Brazil
dc.description.affiliationInst Canc São Paulo ICESP, Dept Radiat Oncol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Brazilian Cochrane Ctr & Discipline Emergency Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Radiat Oncol, Fac Med, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Brazilian Cochrane Ctr & Discipline Emergency Med, São Paulo, Brazil
dc.identifier.doi10.1016/j.radonc.2013.11.010
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000333792100003
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