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Title: A Population-Based Cohort Study on Chronic Obstructive Pulmonary Disease in Latin America: Methods and Preliminary Results. the PLATINO Study Phase II
Authors: Menezes, Ana Maria Baptista
Muino, Adriana
Lopez-Varela, Maria Victorina
Valdivia, Gonzalo
Lisboa, Carmen
Jardime, Jose Roberto [UNIFESP]
Oca, Maria Montes de
Talamo, Carlos
Wehrmeister, Fernando Cesar
Perez-Padilla, Rogelio
Platinoo, Equipo del Estudio
Univ Fed Pelotas
Ctr Hosp Pereira Rossell
Univ Republica
Univ Catol Santiago
Universidade Federal de São Paulo (UNIFESP)
Cent Univ Venezuela
Inst Nacl Enfermedades Resp
Keywords: Chronic obstructive pulmonary disease
Longitudinal studies
Latin America
Issue Date: 1-Jan-2014
Publisher: Ediciones Doyma S A
Citation: Archivos de Bronconeumologia. Barcelona: Ediciones Doyma S A, v. 50, n. 1, p. 10-17, 2014.
Abstract: Background: the PLATINO baseline study, conducted from 2003-2005 in five Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD).Methods/design: A follow-up study was conducted in three out of the five centers (Montevideo, Santiago, and São Paulo) after a period of 5, 6 and 9 years, respectively, aimed at verifying the stability of the COPD diagnosis over time, the evolution of the disease in terms of survival, morbidity and respiratory function, and the analyses of inflammatory and genetic biomarkers in the blood. Some questions were added to the original questionnaire and death certificates were obtained from the national official registries.Results: the fieldwork has been concluded in the three centers. From the original samples in the PLATING study phase I, we were able to locate and interview 85.6% of patients in Montevideo, 84.7% in Santiago and 77.7% in São Paulo. Individuals who could not be located had higher education levels in Brazil, and were more likely to be current smokers in Santiago and São Paulo than in Montevideo. the overall quality of spirometries was >= 80% according to American Thoracic Society criteria. the number of deaths was 71 (Montevideo), 95 (Santiago) and 135 (São Paulo), with death certificates obtained from the national mortality registries for 76.1%, 88.3% and 91.8% of cases in Montevideo, Santiago and São Paulo, respectively.Conclusions: This study shows that is possible to perform population-based longitudinal studies in Latin American with high follow-up rates and high-quality spirometry data. the adequacy of national mortality registries varies among centers in Latin America. (C) 2013 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.
ISSN: 0300-2896
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