Please use this identifier to cite or link to this item:
|Title:||Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas|
|Authors:||Machado Rocha, Francisco Carlos [UNIFESP]|
Santos Junior, Jair Guilherme dos
Stefano, Sergio Carlos [UNIFESP]
Silveira, Dartiu Xavier da [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fac Med Sci Santa Casa São Paulo
Cell cycle arrest
|Citation:||Journal of Neuro-oncology. New York: Springer, v. 116, n. 1, p. 11-24, 2014.|
|Abstract:||To evaluate, through a systematic review of the literature, the antitumoral effects of cannabinoids on gliomas. Research included the following electronic databases: PUBMED, EMBASE, LILACS and the Cochrane Collaboration Controlled Trials Register. All published studies involving the antitumoral effects (cellular and molecular mechanisms) of cannabinoids were considered for this review. the bibliography search strategy included all publications of each of these databases until December 31, 2012. From 2,260 initially identified articles, 35 fulfilled the inclusion criteria for this review. All the studies included in this systematic review were experimental (in vivo and/or in vitro), except for one pilot clinical trial phase I/II involving humans. in all experimental studies included, cannabinoids exerted antitumoral activity in vitro and/or antitumoral evidence in vivo in several models of tumor cells and tumors. the antitumor activity included: antiproliferative effects (cell cycle arrest), decreased viability and cell death by toxicity, apoptosis, necrosis, autophagy, as well as antiangiogenic and antimigratory effects. Antitumoral evidence included: reduction in tumor size, antiangiogenic, and antimetastatic effects. Additionally, most of the studies described that the canabinnoids exercised selective antitumoral action in several distinct tumor models. Thereby, normal cells used as controls were not affected. the safety factor in the cannabinoids' administration has also been demonstrated in vivo. the various cannabinoids tested in multiple tumor models showed antitumoral effects both in vitro and in vivo. These findings indicate that cannabinoids are promising compounds for the treatment of gliomas.|
|Appears in Collections:||Em verificação - Geral|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.