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Title: Low-level light-emitting diode therapy increases mRNA expressions of IL-10 and type I and III collagens on Achilles tendinitis in rats
Authors: Xavier, Murilo
Souza, Renato Aparecido de
Pires, Viviane Araujo
Santos, Ana Paula
Aimbire, Flavio [UNIFESP]
Silva, Jose Antonio
Albertini, Regiane
Villaverde, Antonio Balbin
Univ Fed Vales Jequitinhonha & Mucuri
Univ Camilo Castelo Branco
Inst Fed Educ Ciencia & Tecnol Sul Minas Gerais
Universidade Federal de São Paulo (UNIFESP)
Nove de Julho Univ
Keywords: Inflammation
Light-tissue interaction
Tendinopathies and tendinitis
Tissue repair
Issue Date: 1-Jan-2014
Publisher: Springer
Citation: Lasers in Medical Science. London: Springer London Ltd, v. 29, n. 1, p. 85-90, 2014.
Abstract: The present study investigated the effects of low-level light-emitting diode (LED) therapy (880 +/- 10 nm) on interleukin (IL)-10 and type I and III collagen in an experimental model of Achilles tendinitis. Thirty male Wistar rats were separated into six groups (n = 5), three groups in the experimental period of 7 days, control group, tendinitis-induced group, and LED therapy group, and three groups in the experimental period of 14 days, tendinitis group, LED therapy group, and LED group with the therapy starting at the 7th day after tendinitis induction (LEDT delay). Tendinitis was induced in the right Achilles tendon using an intratendinous injection of 100 mu L of collagenase. the LED parameters were: optical power of 22 mW, spot area size of 0.5 cm(2), and irradiation time of 170 s, corresponding to 7.5 J/cm(2) of energy density. the therapy was initiated 12 h after the tendinitis induction, with a 48-h interval between irradiations. the IL-10 and type I and III collagen mRNA expression were evaluated by real-time polymerase chain reaction at the 7th and 14th days after tendinitis induction. the results showed that LED irradiation increased IL-10 (p < 0.001) in treated group on 7-day experimental period and increased type I and III collagen mRNA expression in both treated groups of 7- and 14-day experimental periods (p < 0.05), except by type I collagen mRNA expression in LEDT delay group. LED (880 nm) was effective in increasing mRNA expression of IL-10 and type I and III collagen. Therefore, LED therapy may have potentially therapeutic effects on Achilles tendon injuries.
ISSN: 0268-8921
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