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dc.contributor.authorGrande, Antonio Jose
dc.contributor.authorSilva, Valter [UNIFESP]
dc.contributor.authorRiera, Rachel
dc.contributor.authorMedeiros, Alessandra [UNIFESP]
dc.contributor.authorVitoriano, Simone G. P.
dc.contributor.authorPeccin, Maria S. [UNIFESP]
dc.contributor.authorMaddocks, Matthew
dc.identifier.citationCochrane Database of Systematic Reviews. Hoboken: Wiley-Blackwell, n. 11, 26 p., 2014.
dc.description.abstractBackgroundCancer cachexia is amulti-factorial syndrome characterised by an ongoing loss of skeletal muscle mass, with or without a loss of fat mass, which leads to progressive functional impairment. Physical exercise may attenuate the effects of cancer cachexia via several mechanisms, including the modulation of muscle metabolism, insulin sensitivity and levels of inflammation.ObjectivesThe primary objective was to determine the effects of exercise, compared to usual care or no treatment, on lean body mass, the main biomarker of cachexia, in adults with cancer. Secondary objectives, subject to the availability of data, were to examine the acceptability and safety of exercise in this setting and to compare effects according to the characteristics of the exercise intervention or patient population.Search methodsWe searched the databases CENTRAL (Issue 6, 2014), MEDLINE (1946 to June 2014), EMBASE (1974 to June 2014), DARE and HTA (Issue 6, 2014), ISI Web of Science (1900 to June 2014), LILACS (1985 to 28 June 2014), PEDro (inception to 28 June 2014), SciVerse SCOPUS (inception to 28 June 2014), Biosis Previews PreMEDLINE (1969 to June 2014) and Open Grey (inception to 28 June 2014). We also searched for ongoing studies, checked reference lists and contacted experts to seek potentially relevant research.Selection criteriaWe included randomised controlled trials (RCTs) in adults meeting the clinical criteria for cancer cachexia comparing a programme of exercise as a sole or adjunct intervention to no treatment or an active control. We imposed no language restriction.Data collection and analysisTwo review authors independently assessed titles and abstracts of articles for relevance and extracted data on study design, participants, interventions and outcomes from potentially relevant articles.Main resultsWe screened 3154 individual references, of which we removed 3138 after title screening and read 16 in full. We found no trials that met the inclusion criteria.Authors' conclusionsThere is insufficient evidence to determine the safety and effectiveness of exercise for patients with cancer cachexia. Randomised controlled trials (i.e., preferably parallel-group or cluster-randomised trials) are required to test the effectiveness of exercise in this group. There are ongoing studies on the topic, so we will update this review to incorporate the findings.en
dc.description.sponsorshipNational Institute for Health Research (NIHR)
dc.relation.ispartofCochrane Database of Systematic Reviews
dc.rightsAcesso restrito
dc.titleExercise for cancer cachexia in adultsen
dc.contributor.institutionUniv Extremo Sul Catarinense
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBrazilian Cochrane Ctr
dc.contributor.institutionAPS Santa Marcelina
dc.contributor.institutionKings Coll London
dc.description.affiliationUniv Extremo Sul Catarinense, Dept Publ Hlth, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Evidence Based Hlth, São Paulo, Brazil
dc.description.affiliationBrazilian Cochrane Ctr, Ctr Estudos Saude Baseada Evidencias Avaliacao Te, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, Santos, Brazil
dc.description.affiliationAPS Santa Marcelina, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Human Movement Sci, Santos, Brazil
dc.description.affiliationKings Coll London, Cicely Saunders Inst, Dept Palliat Care Policy & Rehabil, London WC2R 2LS, England
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Evidence Based Hlth, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Human Movement Sci, Santos, Brazil
dc.description.sourceWeb of Science
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