Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/37130
Title: Role of Training and Detraining on Inflammatory and Metabolic Profile in Infarcted Rats: Influences of Cardiovascular Autonomic Nervous System
Authors: Rodrigues, Bruno
Santana, Aline Alves [UNIFESP]
Santamarina, Aline Boveto [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Caperuto, Erico Chagas
Souza, Claudio Teodoro de
Barboza, Catarina de Andrade
Rocha, Leandro Yanase
Figueroa, Diego
Mostarda, Cristiano
Irigoyen, Maria Claudia
Lira, Fabio Santos
Sao Judas Tadeu Univ USJT
Universidade Federal de São Paulo (UNIFESP)
Univ Extremo Catarinense UNESC
Universidade de São Paulo (USP)
Issue Date: 1-Jan-2014
Publisher: Hindawi Publishing Corporation
Citation: Mediators of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2014.
Abstract: The aim of this study was to evaluate the effects of exercise training (ET, 50-70% of VO2max, 5 days/week) and detraining (DT) on inflammatory and metabolic profile after myocardial infarction (MI) in rats. Male Wistar rats were divided into control (C, n = 8), sedentary infarcted (SI, n = 9), trained infarcted (TI, n = 10; 3 months of ET), and detrained infarcted (DI, n = 11; 2 months of ET + 1 month of DT). After ET and DT protocols, ventricular function and inflammation, cardiovascular autonomic modulation (spectral analysis), and adipose tissue inflammation and lipolytic pathway were evaluated. ET after MI improved cardiac and vascular autonomic modulation, and these benefits were correlated with reduced inflammatory cytokines on the heart and adipose tissue. These positive changes were sustained even after 1 month of detraining. No expressive changes were observed in oxidative stress and lipolytic pathway in experimental groups. in conclusion, our results strongly suggest that the autonomic improvement promoted by ET, and maintained even after the detraining period, was associated with reduced inflammatory profile in the left ventricle and adipose tissue of rats subjected to MI. These data encourage enhancing cardiovascular autonomic function as a therapeutic strategy for the treatment of inflammatory process triggered by MI.
URI: http://repositorio.unifesp.br/handle/11600/37130
ISSN: 0962-9351
Other Identifiers: http://dx.doi.org/10.1155/2014/207131
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