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Title: The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models
Authors: Real, Fernando [UNIFESP]
Vidal, Ramon Oliveira
Carazzolle, Marcelo Falsarella
Mondego, Jorge Mauricio Costa
Costa, Gustavo Gilson Lacerda
Herai, Roberto Hirochi
Wurtele, Martin [UNIFESP]
Carvalho, Lucas Miguel de
Ferreira, Renata Carmona [UNIFESP]
Mortara, Renato Arruda [UNIFESP]
Barbieri, Clara Lucia [UNIFESP]
Mieczkowski, Piotr
Silveira, Jose Franco da [UNIFESP]
Briones, Marcelo Ribeiro da Silva [UNIFESP]
Pereira, Goncalo Amarante Guimaraes
Bahia, Diana [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Inst Agron Campinas
Univ Calif San Diego
Univ N Carolina
Universidade Federal de Minas Gerais (UFMG)
Keywords: genome
Leishmania amazonensis
heat-shock protein
Issue Date: 1-Dec-2013
Publisher: Oxford Univ Press
Citation: Dna Research. Oxford: Oxford Univ Press, v. 20, n. 6, p. 567-581, 2013.
Abstract: We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of Brazil. L. (L.) amazonensis shares features with Leishmania (L.) mexicana but also exhibits unique characteristics regarding geographical distribution and clinical manifestations of cutaneous lesions (e.g. borderline disseminated cutaneous leishmaniasis). Predicted genes were scored for orthologous gene families and conserved domains in comparison with other human pathogenic Leishmania spp. Carboxypeptidase, aminotransferase, and 3'-nucleotidase genes and ATPase, thioredoxin, and chaperone-related domains were represented more abundantly in L. (L.) amazonensis and L. (L.) mexicana species. Phylogenetic analysis revealed that these two species share groups of amastin surface proteins unique to the genus that could be related to specific features of disease outcomes and host cell interactions. Additionally, we describe a hypothetical hybrid interactome of potentially secreted L. (L.) amazonensis proteins and host proteins under the assumption that parasite factors mimic their mammalian counterparts. the model predicts an interaction between an L. (L.) amazonensis heat-shock protein and mammalian Toll-like receptor 9, which is implicated in important immune responses such as cytokine and nitric oxide production. the analysis presented here represents valuable information for future studies of leishmaniasis pathogenicity and treatment.
ISSN: 1340-2838
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